AKAP8L

AKAP8L
Identifiers
Aliases	AKAP8L , HA95, HAP95, NAKAP, NAKAP95, A-kinase anchoring protein 8 like
External IDs	OMIM: 609475; MGI: 1860606; HomoloGene: 8658; GeneCards: AKAP8L; OMA:AKAP8L - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.12 Start 15,380,050 bp [1] End 15,419,141 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 32,321,424 bp [2] End 32,350,607 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right uterine tube right lobe of thyroid gland anterior pituitary left lobe of thyroid gland sural nerve right testis left testis right adrenal cortex gastric mucosa Top expressed in superior frontal gyrus neural layer of retina primary visual cortex entorhinal cortex spermatid cerebellar cortex muscle of thigh perirhinal cortex central gray substance of midbrain spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding lamin binding histone deacetylase binding DEAD/H-box RNA helicase binding DNA binding protein binding RNA binding protein kinase A regulatory subunit binding Cellular component nuclear matrix chromatin nuclear speck PML body nucleus cytoplasm ribonucleoprotein complex Biological process positive regulation of histone deacetylation nuclear membrane disassembly regulation of mRNA export from nucleus mitotic chromosome condensation cell cycle G2/M phase transition positive regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of transcription, DNA-templated RNA splicing mRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26993 54194 Ensembl ENSG00000011243 ENSMUSG00000002625 UniProt Q9ULX6 Q9R0L7 RefSeq (mRNA) NM_001291478 NM_014371 NM_017476 RefSeq (protein) NP_001278407 NP_055186 n/a Location (UCSC) Chr 19: 15.38 – 15.42 Mb Chr 17: 32.32 – 32.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

A-kinase anchor protein 8-like is a protein that in humans is encoded by the AKAP8L gene. ^{[5] [6] [7]}

Interactions

AKAP8L has been shown to interact with:

• DHX9, ^{[5] [8]} and
• Thymopoietin. ^{[9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000011243 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002625 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element". The Journal of Biological Chemistry. 275 (28): 21396–21401. doi: 10.1074/jbc.M909887199 . PMID   10748171.
6. Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (Jan 2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biology of the Cell. 92 (1): 27–37. doi:10.1016/S0248-4900(00)88761-4. PMID   10761695. S2CID   1354592.
7. "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like".
8. Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry. 276 (33): 30694–700. doi: 10.1074/jbc.M102809200 . PMID   11402034.
9. Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21 (21): 3703–13. doi: 10.1242/jcs.113.21.3703 . PMID   11034899.
10. Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–88. doi:10.1083/jcb.200210026. PMC   2172640 . PMID   12538639.

External links

• Human AKAP8L genome location and AKAP8L gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology. 16 (13): 1338–1342. doi:10.1038/4315. PMID   9853615. S2CID   20001769.
• Seki N, Ueki N, Yano K, Saito T, Masuho Y, Muramatsu M (2000). "cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region". Journal of Human Genetics. 45 (1): 0031–0037. doi: 10.1007/s100380070040 . PMID   10697960.
• Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry. 276 (33): 30694–30700. doi: 10.1074/jbc.M102809200 . PMID   11402034.
• Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Molecular Vision. 8: 185–95. PMID   12107412.
• Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–188. doi:10.1083/jcb.200210026. PMC   2172640 . PMID   12538639.
• Martins SB, Marstad A, Collas P (Sep 2003). "In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling". Biochemistry. 42 (35): 10456–10461. doi:10.1021/bi0350699. PMID   12950172.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Sayer JA, Manczak M, Akileswaran L, Reddy PH, Coghlan VM (2006). "Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis". Neuromolecular Medicine. 7 (4): 297–310. doi:10.1385/NMM:7:4:297. PMID   16391387. S2CID   22889682.