AKAP8L

AKAP8L
Identifiers
Aliases	AKAP8L , HA95, HAP95, NAKAP, NAKAP95, A-kinase anchoring protein 8 like
External IDs	OMIM: 609475 MGI: 1860606 HomoloGene: 8658 GeneCards: AKAP8L
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,419,141 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	32,350,607 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; anterior pituitary; ; left lobe of thyroid gland; ; sural nerve; ; gastric mucosa; ; canal of the cervix; ; right lung; ; ganglionic eminence; ; body of stomach;
	Top expressed in
	superior frontal gyrus; ; entorhinal cortex; ; spermatid; ; cerebellar cortex; ; spermatocyte; ; superior colliculus; ; habenula; ; olfactory tubercle; ; subiculum; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding ; lamin binding ; histone deacetylase binding ; DEAD/H-box RNA helicase binding ; DNA binding ; protein binding ; RNA binding ; protein kinase A regulatory subunit binding ;
Cellular component	nuclear matrix ; chromatin ; nuclear speck ; PML body ; nucleus ; cytoplasm ; ribonucleoprotein complex ;
Biological process	positive regulation of histone deacetylation ; nuclear membrane disassembly ; regulation of mRNA export from nucleus ; mitotic chromosome condensation ; cell cycle G2/M phase transition ; positive regulation of transcription by RNA polymerase II ; transcription, DNA-templated ; regulation of transcription, DNA-templated ; RNA splicing ; mRNA processing ;
	Sources:Amigo / QuickGO
Orthologs
	26993
	54194
	ENSG00000011243
	ENSMUSG00000002625
	Q9ULX6
	Q9R0L7
	NM_001291478 ; NM_014371
	NM_017476
	NP_001278407 ; NP_055186
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

A-kinase anchor protein 8-like is a protein that in humans is encoded by the AKAP8L gene.^[5]^[6]^[7]

Interactions

AKAP8L has been shown to interact with:

DHX9,^[5]^[8] and
Thymopoietin.^[9]^[10]

Related Research Articles

Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a protein that in humans is encoded by the TMPO gene. LAP2 is an inner nuclear membrane (INM) protein.

Lamin-B receptor is a protein, and in humans, it is encoded by the LBR gene.

Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene. It is found in the cell nucleus that binds to pre-messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles. The simian homolog is known as protein H16. Both proteins bind to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein responsible for most gene transcription. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promoting strong DNA binding result in weak RNA binding.

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.

60S ribosomal protein L5 is a protein that in humans is encoded by the RPL5 gene.

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.

Nucleolin is a protein that in humans is encoded by the NCL gene.

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene.

ATP-dependent RNA helicase A is an enzyme that in humans is encoded by the DHX9 gene.

cAMP-dependent protein kinase type II-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR2B gene.

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.

ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene.

A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.

Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000011243 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002625 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element". The Journal of Biological Chemistry. 275 (28): 21396–21401. doi: 10.1074/jbc.M909887199 . PMID 10748171.
↑ Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (Jan 2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biology of the Cell. 92 (1): 27–37. doi:10.1016/S0248-4900(00)88761-4. PMID 10761695. S2CID 1354592.
↑ "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like".
↑ Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry. 276 (33): 30694–700. doi: 10.1074/jbc.M102809200 . PMID 11402034.
↑ Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21 (21): 3703–13. doi: 10.1242/jcs.113.21.3703 . PMID 11034899.
↑ Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–88. doi:10.1083/jcb.200210026. PMC 2172640 . PMID 12538639.

External links

Human AKAP8L genome location and AKAP8L gene details page in the UCSC Genome Browser .

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology. 16 (13): 1338–1342. doi:10.1038/4315. PMID 9853615. S2CID 20001769.
Seki N, Ueki N, Yano K, Saito T, Masuho Y, Muramatsu M (2000). "cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region". Journal of Human Genetics. 45 (1): 0031–0037. doi: 10.1007/s100380070040 . PMID 10697960.
Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry. 276 (33): 30694–30700. doi: 10.1074/jbc.M102809200 . PMID 11402034.
Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Molecular Vision. 8: 185–95. PMID 12107412.
Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–188. doi:10.1083/jcb.200210026. PMC 2172640 . PMID 12538639.
Martins SB, Marstad A, Collas P (Sep 2003). "In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling". Biochemistry. 42 (35): 10456–10461. doi:10.1021/bi0350699. PMID 12950172.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Sayer JA, Manczak M, Akileswaran L, Reddy PH, Coghlan VM (2006). "Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis". Neuromolecular Medicine. 7 (4): 297–310. doi:10.1385/NMM:7:4:297. PMID 16391387. S2CID 22889682.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000011243 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002625 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10748171-5] 1 2 Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element". The Journal of Biological Chemistry. 275 (28): 21396–21401. doi: 10.1074/jbc.M909887199 . PMID 10748171.

[pmid10761695-6] Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (Jan 2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biology of the Cell. 92 (1): 27–37. doi:10.1016/S0248-4900(00)88761-4. PMID 10761695. S2CID 1354592.

[entrez-7] "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like".

[pmid11402034-8] Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry. 276 (33): 30694–700. doi: 10.1074/jbc.M102809200 . PMID 11402034.

[pmid11034899-9] Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21 (21): 3703–13. doi: 10.1242/jcs.113.21.3703 . PMID 11034899.

[pmid12538639-10] Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–88. doi:10.1083/jcb.200210026. PMC 2172640 . PMID 12538639.

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AKAP8L

Contents

Interactions

Related Research Articles

References

External links

Further reading