ANXA8L2

ANXA8L1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W3W,%%s1W45, 1W3W
Identifiers
Aliases	ANXA8L1 , ANXA8, ANXA8L2, VAC-beta, bA145E20.2, annexin A8-like 1, annexin A8 like 1
External IDs	MGI: 1201374 HomoloGene: 20393 GeneCards: ANXA8L1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	46,391,784 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	33,822,528 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; placenta; ; right lung; ; vagina; ; upper lobe of left lung; ; minor salivary glands; ; urinary bladder; ; right uterine tube; ; thymus; ; prostate;
	Top expressed in
	corneal stroma; ; lip; ; conjunctival fornix; ; ankle; ; ankle joint; ; skin of back; ; skin of abdomen; ; esophagus; ; female urethra; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium-dependent phospholipid binding ; metal ion binding ; calcium ion binding ; phosphatidylinositol-4,5-bisphosphate binding ; phosphatidylinositol-3,4,5-trisphosphate binding ; phosphatidylinositol-3,4-bisphosphate binding ; actin filament binding ;
Cellular component	extracellular exosome ; intracellular anatomical structure ; cytosol ; plasma membrane ; late endosome membrane ; collagen-containing extracellular matrix ;
Biological process	endosome organization ; endosomal transport ; negative regulation of serine-type endopeptidase activity ; negative regulation of phospholipase A2 activity ; hemostasis ; blood coagulation ;
	Sources:Amigo / QuickGO
Orthologs
	728113
	11752
	ENSG00000264230
	ENSMUSG00000021950
	Q5VT79 ; P13928
	O35640
	NM_001039801 ; NM_001098845 ; NM_001278923 ; NM_001278924 ; NM_001630 Contents References ; External links ; Further reading ;
	NM_001281845 ; NM_013473
NP_001092315 ; NP_001265852 ; NP_001265853 ; NP_001035173 ; NP_001258631 ;
	NP_001258632
	NP_001268774 ; NP_038501
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 13, 2024

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.^[5]

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.^[5]

Related Research Articles

<span class="mw-page-title-main">Annexin A1</span> Protein-coding gene in the species Homo sapiens

Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans.

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.

Annexin A5 is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. The function of the protein is unknown; however, annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These properties have been found by in vitro experiments.

Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.

Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.

Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.

Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene.

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.

Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.

Copine-8 is a protein that in humans is encoded by the CPNE8 gene.

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.

Annexin A9 is a protein that in humans is encoded by the ANXA9 gene.

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.

Phospholipid scramblase 4, also known as Ca²⁺-dependent phospholipid scramblase 4, is a protein that is encoded in humans by the PLSCR4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000264230 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021950 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ANXA8 annexin A8".

External links

Human ANXA8 genome location and ANXA8 gene details page in the UCSC Genome Browser .
Human ANXA8L1 genome location and ANXA8L1 gene details page in the UCSC Genome Browser .

Gerke V, Moss SE (2002). "Annexins: from structure to function". Physiol. Rev. 82 (2): 331–71. doi:10.1152/physrev.00030.2001. PMID 11917092.
Gerke V, Creutz CE, Moss SE (2005). "Annexins: linking Ca2+ signaling to membrane dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 449–61. doi:10.1038/nrm1661. PMID 15928709. S2CID 37526262.
Chang KS, Wang G, Freireich EJ, et al. (1992). "Specific expression of the annexin VIII gene in acute promyelocytic leukemia". Blood. 79 (7): 1802–10. doi: 10.1182/blood.V79.7.1802.1802 . PMID 1313714.
Chambers JA, Gardner E, Hauptmann R, et al. (1993). "TaqI polymorphisms at the annexin VIII locus (ANX8)". Hum. Mol. Genet. 1 (7): 550. doi: 10.1093/hmg/1.7.550 . PMID 1364010.
Hauptmann R, Maurer-Fogy I, Krystek E, et al. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". Eur. J. Biochem. 185 (1): 63–71. doi: 10.1111/j.1432-1033.1989.tb15082.x . PMID 2530088.
Sarkar A, Yang P, Fan YH, et al. (1994). "Regulation of the expression of annexin VIII in acute promyelocytic leukemia". Blood. 84 (1): 279–86. doi: 10.1182/blood.V84.1.279.279 . PMID 8018923.
Reutelingsperger CP, van Heerde W, Hauptmann R, et al. (1994). "Differential tissue expression of Annexin VIII in human". FEBS Lett. 349 (1): 120–4. Bibcode:1994FEBSL.349..120R. doi: 10.1016/0014-5793(94)00559-1 . PMID 8045287. S2CID 8928858.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Stein T, Price KN, Morris JS, et al. (2006). "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer". Clin. Cancer Res. 11 (19 Pt 1): 6872–9. doi: 10.1158/1078-0432.CCR-05-0547 . PMID 16203777.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Goebeler V, Ruhe D, Gerke V, Rescher U (2006). "Annexin A8 displays unique phospholipid and F-actin binding properties". FEBS Lett. 580 (10): 2430–4. Bibcode:2006FEBSL.580.2430G. doi: 10.1016/j.febslet.2006.03.076 . PMID 16638567. S2CID 22336528.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000264230 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021950 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ANXA8 annexin A8".

[1]

[2]

[3]

[4]

[5]

ANXA8L2

Contents

Related Research Articles

References

External links

Further reading