AP1B1

AP1B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HMY, 4P6Z
Identifiers
Aliases	AP1B1 , ADTB1, AP105A, BAM22, CLAPB2, adaptor related protein complex 1 beta 1 subunit, adaptor related protein complex 1 subunit beta 1, KIDAR
External IDs	OMIM: 600157 MGI: 1096368 HomoloGene: 21972 GeneCards: AP1B1
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.2 Start 29,327,680 bp [1] End 29,423,179 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 4,936,824 bp [2] End 4,992,791 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle frontal gyrus Brodmann area 10 frontal pole spleen lymph node Left adrenal gland cingulate gyrus monocyte anterior pituitary body of stomach Top expressed in superior frontal gyrus lip yolk sac cerebellar cortex entorhinal cortex superior colliculus pontine nuclei medulla oblongata inferior colliculus dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity protein binding protein kinase binding clathrin binding Cellular component trans-Golgi network membrane membrane Golgi membrane lysosomal membrane clathrin-coated vesicle membrane membrane coat cytoplasmic vesicle membrane cytoplasmic vesicle clathrin adaptor complex Golgi apparatus cytosol intracellular membrane-bounded organelle Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II mitigation of host defenses by virus heart development determination of left/right symmetry protein transport intracellular protein transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 162 11764 Ensembl ENSG00000100280 ENSMUSG00000009090 UniProt Q10567 O35643 RefSeq (mRNA) NM_145730 NM_001127 NM_001166019 NM_001243043 NM_001243044 NM_007454 NM_001355659 NM_001355660 RefSeq (protein) NP_001118 NP_001159491 NP_663782 NP_001365491 NP_001365492 NP_001365493 NP_001365494 NP_001365495 NP_001229972 NP_001229973 NP_031480 NP_001342588 NP_001342589 Location (UCSC) Chr 22: 29.33 – 29.42 Mb Chr 11: 4.94 – 4.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. ^{[5] [6] [7]}

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist. ^[7]

Interactions

AP1B1 has been shown to interact with KIF13A ^[8] and AP1G1. ^{[9] [10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000100280 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009090 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP (January 1995). "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene". Hum Mol Genet. 3 (8): 1393–9. doi:10.1093/hmg/3.8.1393. PMID   7987321.
6. Peyrard M, Pan HQ, Kedra D, Fransson I, Swahn S, Hartman K, Clifton SW, Roe BA, Dumanski JP (February 1997). "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12". Genomics. 36 (1): 112–7. doi:10.1006/geno.1996.0431. PMID   8812422.
7. "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit".
8. Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; Takio K; Hirokawa N (November 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. UNITED STATES. 103 (4): 569–81. doi: 10.1016/S0092-8674(00)00161-6 . ISSN   0092-8674. PMID   11106728.
9. Takatsu, H; Sakurai M; Shin H W; Murakami K; Nakayama K (September 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. UNITED STATES. 273 (38): 24693–700. doi: 10.1074/jbc.273.38.24693 . ISSN   0021-9258. PMID   9733768.
10. Fölsch, H; Ohno H; Bonifacino J S; Mellman I (October 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. UNITED STATES. 99 (2): 189–98. doi: 10.1016/S0092-8674(00)81650-5 . ISSN   0092-8674. PMID   10535737.
11. Page, L J; Robinson M S (November 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. UNITED STATES. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. ISSN   0021-9525. PMC   2120623 . PMID   7593184.

Further reading

• Kirchhausen T (2000). "Clathrin". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID   10966473.
• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC   1083955 . PMID   11463741.
• Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. doi: 10.1051/medsci/2003191100 . PMID   12836198.
• Lim DS, Kirsch DG, Canman CE, et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. Bibcode:1998PNAS...9510146L. doi: 10.1073/pnas.95.17.10146 . PMC   21476 . PMID   9707615.
• Takatsu H, Sakurai M, Shin HW, et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. 273 (38): 24693–700. doi: 10.1074/jbc.273.38.24693 . PMID   9733768.
• Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. Bibcode:1998PNAS...9511229C. doi: 10.1073/pnas.95.19.11229 . PMC   21624 . PMID   9736718.
• Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Curr. Biol. 8 (22): 1235–8. doi: 10.1016/S0960-9822(07)00517-9 . PMID   9811606.
• Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. doi: 10.1016/S0960-9822(07)00518-0 . PMID   9811611.
• Laporte SA, Oakley RH, Zhang J, et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. Bibcode:1999PNAS...96.3712L. doi: 10.1073/pnas.96.7.3712 . PMC   22359 . PMID   10097102.
• Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi: 10.1016/S0092-8674(00)81650-5 . PMID   10535737.
• Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi: 10.1074/jbc.274.53.37538 . PMID   10608806.
• Lai MM, Luo HR, Burnett PE, et al. (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". J. Biol. Chem. 275 (44): 34017–20. doi: 10.1074/jbc.C000429200 . PMID   10931822.
• Nakagawa T, Setou M, Seog D, et al. (2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. 103 (4): 569–81. doi: 10.1016/S0092-8674(00)00161-6 . PMID   11106728.
• Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID   11409905.
• Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly". Mol. Biol. Cell. 12 (7): 1925–35. doi:10.1091/mbc.12.7.1925. PMC   55640 . PMID   11451993.
• Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1". J. Biol. Chem. 277 (24): 21158–66. doi: 10.1074/jbc.M112145200 . PMID   11912197.

External links

• Human AP1B1 genome location and AP1B1 gene details page in the UCSC Genome Browser .