AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene. [5] [6]
AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene. [5] [6]
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [7]
AP1G1 has been shown to interact with:
Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules from one subcellular location to another. These complexes concentrate the correct cargo molecules in vesicles that bud or extrude off of one organelle and travel to another location, where the cargo is delivered. While some of the details of how these adaptor proteins achieve their trafficking specificity has been worked out, there is still much to be learned.
ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.
AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.
AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.
AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene.
ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.
ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.
AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.
AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.
AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene.
AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene.
Coatomer subunit gamma-2 is a protein that in humans is encoded by the COPG2 gene.
AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.
AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene.
Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG gene.
AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.
Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. These proteins are synthesized in the ribosomes, processed in the endoplasmic reticulum and transported from the Golgi apparatus to the trans-Golgi network, and from there via small carrier vesicles to their final destination compartment. The association between adaptins and clathrin are important for vesicular cargo selection and transporting. Clathrin coats contain both clathrin and adaptor complexes that link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Therefore, adaptor proteins are responsible for the recruitment of cargo molecules into a growing clathrin-coated pits. The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and the monomeric GGA adaptors. Adaptins are distantly related to the other main type of vesicular transport proteins, the coatomer subunits, sharing between 16% and 26% of their amino acid sequence.
The C-terminal domain ofBeta2-adaptin is a protein domain is involved in cell trafficking by aiding import and export of substances in and out of the cell.
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