AP1G1

AP1G1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IU1
Identifiers
Aliases	AP1G1 , ADTG, CLAPG1, adaptor related protein complex 1 gamma 1 subunit, adaptor related protein complex 1 subunit gamma 1, USRISD
External IDs	OMIM: 603533; MGI: 101919; HomoloGene: 47995; GeneCards: AP1G1; OMA:AP1G1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.2 Start 71,729,000 bp [1] End 71,809,201 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 D3|8 57.26 cM Start 110,505,186 bp [2] End 110,590,836 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Achilles tendon epithelium of colon sperm corpus epididymis islet of Langerhans sural nerve left testis middle temporal gyrus right testis Top expressed in genital tubercle tail of embryo cumulus cell granulocyte neural layer of retina dentate gyrus of hippocampal formation granule cell Paneth cell ventricular zone spermatocyte right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity GTP-dependent protein binding protein binding kinesin binding Cellular component recycling endosome clathrin-coated endocytic vesicle membrane Golgi apparatus trans-Golgi network membrane membrane intracellular membrane-bounded organelle Golgi membrane lysosomal membrane AP-type membrane coat adaptor complex clathrin-coated vesicle membrane membrane coat cytoplasmic vesicle membrane cytoplasmic vesicle clathrin-coated vesicle clathrin adaptor complex cytoplasm cytosol AP-1 adaptor complex Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II mitigation of host defenses by virus Golgi to lysosome transport positive regulation of natural killer cell degranulation melanosome organization endosome to melanosome transport protein transport intracellular protein transport positive regulation of natural killer cell mediated cytotoxicity vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 164 11765 Ensembl ENSG00000166747 ENSMUSG00000031731 UniProt O43747 P22892 RefSeq (mRNA) NM_001128 NM_001030007 NM_001301211 NM_009677 RefSeq (protein) NP_001025178 NP_001119 NP_001288140 NP_033807 Location (UCSC) Chr 16: 71.73 – 71.81 Mb Chr 8: 110.51 – 110.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene. ^{[5] [6]}

Function

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. ^[7]

Interactions

AP1G1 has been shown to interact with:

• AP1B1, ^{[6] [8] [9]}
• AP1GBP1, ^{[10] [11]}
• AP1M1, ^{[8] [9]}
• AP1S1, ^{[6] [8] [9]}
• NECAP2, ^[12]
• RABEP1, ^{[10] [13]} and
• Synaptophysin. ^[14]

References

1. GRCh38: Ensembl release 89: ENSG00000166747 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031731 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (Jun 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID   9653655.
6. Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Sep 1998). "Identification and characterization of novel clathrin adaptor-related proteins". The Journal of Biological Chemistry. 273 (38): 24693–700. doi: 10.1074/jbc.273.38.24693 . PMID   9733768.
7. "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit".
8. Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi: 10.1016/s0092-8674(00)81650-5 . PMID   10535737. S2CID   15288582.
9. Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal of Cell Biology. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC   2120623 . PMID   7593184.
10. Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology. 9 (7): 527–31. doi:10.1038/nsb808. PMID   12042876. S2CID   42630285.
11. Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID   10814529.
12. Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". The Journal of Biological Chemistry. 279 (9): 8018–28. doi: 10.1074/jbc.M311873200 . PMID   14665628.
13. Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC   140067 . PMID   12505986.
14. Horikawa HP, Kneussel M, El Far O, Betz H (Nov 2002). "Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin". Molecular and Cellular Neurosciences. 21 (3): 454–62. doi:10.1006/mcne.2002.1191. PMID   12498786. S2CID   54366866.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC   103959 . PMID   9882340.
• Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". The Journal of Cell Biology. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC   2169493 . PMID   10477754.
• Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi: 10.1016/S0092-8674(00)81650-5 . PMID   10535737. S2CID   15288582.
• Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC   2175106 . PMID   10747088.
• Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID   10814529.
• Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N (Nov 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. 103 (4): 569–81. doi: 10.1016/S0092-8674(00)00161-6 . PMID   11106728. S2CID   18245989.
• Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M (Mar 2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". Journal of Virology. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC   115924 . PMID   11222723.
• Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G (May 2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic". The EMBO Journal. 20 (9): 2191–201. doi:10.1093/emboj/20.9.2191. PMC   125242 . PMID   11331585.
• Takatsu H, Futatsumori M, Yoshino K, Yoshida Y, Shin HW, Nakayama K (Jun 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochemical and Biophysical Research Communications. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID   11409905.
• Orzech E, Livshits L, Leyt J, Okhrimenko H, Reich V, Cohen S, Weiss A, Melamed-Book N, Lebendiker M, Altschuler Y, Aroeti B (Aug 2001). "Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins". The Journal of Biological Chemistry. 276 (33): 31340–8. doi: 10.1074/jbc.M101054200 . PMID   11418592.
• Doray B, Kornfeld S (Jul 2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly". Molecular Biology of the Cell. 12 (7): 1925–35. doi:10.1091/mbc.12.7.1925. PMC   55640 . PMID   11451993.
• Shiba Y, Takatsu H, Shin HW, Nakayama K (Mar 2002). "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain". Journal of Biochemistry. 131 (3): 327–36. doi:10.1093/oxfordjournals.jbchem.a003107. PMID   11872161.
• Austin C, Boehm M, Tooze SA (Apr 2002). "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3". Biochemistry. 41 (14): 4669–77. doi:10.1021/bi016064j. PMID   11926829.
• Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M (Jul 2002). "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons". The Journal of Biological Chemistry. 277 (28): 25400–7. doi: 10.1074/jbc.M110793200 . PMID   11950833.
• Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology. 9 (7): 527–31. doi:10.1038/nsb808. PMID   12042876. S2CID   42630285.
• Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Molecular Biology of the Cell. 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC   133614 . PMID   12429846.

External links

• Human AP1G1 genome location and AP1G1 gene details page in the UCSC Genome Browser .