AP2S1

AP2S1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JKR, 2JKT, 2VGL, 2XA7, 4UQI, 4NEE
Identifiers
Aliases	AP2S1 , AP17, CLAPS2, FBH3, FBHOk, HHC3, adaptor related protein complex 2 sigma 1 subunit, adaptor related protein complex 2 subunit sigma 1
External IDs	OMIM: 602242; MGI: 2141861; HomoloGene: 3001; GeneCards: AP2S1; OMA:AP2S1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.32 Start 46,838,136 bp [1] End 46,850,846 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A2 Start 16,472,335 bp [2] End 16,483,219 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right adrenal gland right frontal lobe mucosa of transverse colon human penis right adrenal cortex left adrenal gland left adrenal cortex prefrontal cortex cingulate gyrus Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus granulocyte facial motor nucleus neural tube ventricular zone yolk sac lip stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity clathrin adaptor activity protein binding Cellular component endocytic vesicle membrane cytosol clathrin-coated endocytic vesicle membrane membrane plasma membrane endolysosome membrane membrane coat clathrin-coated pit AP-2 adaptor complex clathrin-coated endocytic vesicle intracellular membrane-bounded organelle Biological process regulation of endocytosis endocytosis antigen processing and presentation of exogenous peptide antigen via MHC class II ephrin receptor signaling pathway mitigation of host defenses by virus clathrin-dependent endocytosis clathrin coat assembly protein transport intracellular protein transport vesicle-mediated transport microtubule-based movement Wnt signaling pathway, planar cell polarity pathway membrane organization low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1175 232910 Ensembl ENSG00000042753 ENSMUSG00000008036 UniProt P53680 P62743 RefSeq (mRNA) NM_001301076 NM_001301078 NM_001301081 NM_004069 NM_021575 NM_198613 RefSeq (protein) NP_001288005 NP_001288007 NP_001288010 NP_004060 NP_067586 NP_941015 Location (UCSC) Chr 19: 46.84 – 46.85 Mb Chr 7: 16.47 – 16.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene. ^{[5] [6] [7]}

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000042753 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008036 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet. 75 (2–3): 132–5. doi:10.1159/000134463. PMID   9040778.
6. Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID   9767099.
7. "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit".

Further reading

• Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat construction in endocytosis". Curr. Opin. Struct. Biol. 10 (2): 220–8. doi:10.1016/S0959-440X(00)00071-3. PMID   10753805.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Byland R, Vance PJ, Hoxie JA, Marsh M (2007). "A Conserved Dileucine Motif Mediates Clathrin and AP-2–dependent Endocytosis of the HIV-1 Envelope Protein". Mol. Biol. Cell. 18 (2): 414–25. doi:10.1091/mbc.E06-06-0535. PMC   1783771 . PMID   17108326.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Batonick M, Favre M, Boge M, et al. (2006). "Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2". Virology. 342 (2): 190–200. doi: 10.1016/j.virol.2005.08.001 . PMID   16139856.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Vendeville A, Rayne F, Bonhoure A, et al. (2005). "HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses". Mol. Biol. Cell. 15 (5): 2347–60. doi:10.1091/mbc.E03-12-0921. PMC   404028 . PMID   15020715.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Collins BM, McCoy AJ, Kent HM, et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell. 109 (4): 523–35. doi: 10.1016/S0092-8674(02)00735-3 . PMID   12086608. S2CID   483953.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins". J. Virol. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC   103959 . PMID   9882340.
• Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC   2120623 . PMID   7593184.
• Kirchhausen T, Nathanson KL, Matsui W, et al. (1989). "Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2612–6. Bibcode:1989PNAS...86.2612K. doi: 10.1073/pnas.86.8.2612 . PMC   286967 . PMID   2495531.
• Kirchhausen T, Davis AC, Frucht S, et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast". J. Biol. Chem. 266 (17): 11153–7. doi: 10.1016/S0021-9258(18)99141-6 . PMID   2040623.

External links

• Human AP2S1 genome location and AP2S1 gene details page in the UCSC Genome Browser .