AP4M1

AP4M1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L81, 4MDR
Identifiers
Aliases	AP4M1 , CPSQ3, MU-4, MU-ARP2, SPG50, adaptor related protein complex 4 mu 1 subunit, adaptor related protein complex 4 subunit mu 1
External IDs	OMIM: 602296 MGI: 1337063 HomoloGene: 3467 GeneCards: AP4M1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,110,345 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	138,178,691 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; ganglionic eminence; ; canal of the cervix; ; body of stomach; ; left lobe of thyroid gland; ; tibial nerve; ; ascending aorta;
	Top expressed in
	spermatid; ; spermatocyte; ; lip; ; yolk sac; ; seminiferous tubule; ; superior frontal gyrus; ; neural tube; ; ganglionic eminence; ; fossa; ; mirror;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein domain specific binding ;
Cellular component	trans-Golgi network ; endosome ; Golgi apparatus ; trans-Golgi network membrane ; endosome lumen ; extracellular exosome ; clathrin adaptor complex ; cytosol ; early endosome ; AP-4 adaptor complex ; membrane ;
Biological process	Golgi to endosome transport ; protein transport ; intracellular protein transport ; transport ; protein targeting ; protein targeting to lysosome ; vesicle-mediated transport ; Golgi to lysosome transport ; protein localization to basolateral plasma membrane ; protein localization ;
	Sources:Amigo / QuickGO
Orthologs
	9179
	11781
	ENSG00000221838
	ENSMUSG00000019518
	O00189
	Q9JKC7
	NM_004722 ; NM_001363671
	NM_021392
	NP_004713 ; NP_001350600
	NP_067367
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 25, 2023

AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.^[5]^[6]^[7]

Function

This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.^[7]

Interactions

AP4M1 has been shown to interact with AP4B1.^[8]

Clinical relevance

The AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.^[9]

Related Research Articles

AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.

AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.

AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene.

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.

AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene.

AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene.

AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene.

AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene.

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.

Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.

AP-3 complex subunit mu-1 is a protein that in humans is encoded by the AP3M1 gene.

AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene.

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.

AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.

AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene.

AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.

AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene.

AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene.

Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. These proteins are synthesized in the ribosomes, processed in the endoplasmic reticulum and transported from the Golgi apparatus to the trans-Golgi network, and from there via small carrier vesicles to their final destination compartment. The association between adaptins and clathrin are important for vesicular cargo selection and transporting. Clathrin coats contain both clathrin and adaptor complexes that link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Therefore, adaptor proteins are responsible for the recruitment of cargo molecules into a growing clathrin-coated pits. The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and the monomeric GGA adaptors. Adaptins are distantly related to the other main type of vesicular transport proteins, the coatomer subunits, sharing between 16% and 26% of their amino acid sequence.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000221838 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019518 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang X, Kilimann MW (Feb 1997). "Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2". FEBS Lett. 402 (1): 57–61. doi: 10.1016/S0014-5793(96)01500-1 . PMID 9013859. S2CID 81844290.
↑ Dell'Angelica EC, Mullins C, Bonifacino JS (Apr 1999). "AP-4, a novel protein complex related to clathrin adaptors". J Biol Chem. 274 (11): 7278–85. doi: 10.1074/jbc.274.11.7278 . PMID 10066790.
1 2 "Entrez Gene: AP4M1 adaptor-related protein complex 4, mu 1 subunit".
↑ Hirst J, Bright NA, Rous B, Robinson MS (August 1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell. 10 (8): 2787–802. doi:10.1091/mbc.10.8.2787. PMC 25515 . PMID 10436028.
↑ Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck G, Ekici A, Brockschmidt FF, Nöthen MM, Munnich A, Strom TM, Reis A, Colleaux L (June 2011). "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature". Am. J. Hum. Genet. 88 (6): 788–95. doi:10.1016/j.ajhg.2011.04.019. PMC 3113253 . PMID 21620353.

External links

Human AP4M1 genome location and AP4M1 gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : O00189 (Human AP-4 complex subunit mu-1) at the PDBe-KB .

Stephens DJ, Banting G (1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120". Biochem. J. 335 (Pt 3): 567–72. doi:10.1042/bj3350567. PMC 1219817 . PMID 9794796.
Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a Fourth Adaptor-related Protein Complex". Mol. Biol. Cell. 10 (8): 2787–802. doi:10.1091/mbc.10.8.2787. PMC 25515 . PMID 10436028.
Aguilar RC, Boehm M, Gorshkova I, et al. (2001). "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4". J. Biol. Chem. 276 (16): 13145–52. doi: 10.1074/jbc.M010591200 . PMID 11139587.
Boehm M, Aguilar RC, Bonifacino JS (2002). "Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs)". EMBO J. 20 (22): 6265–76. doi:10.1093/emboj/20.22.6265. PMC 125733 . PMID 11707398.
Simmen T, Höning S, Icking A, et al. (2002). "AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells". Nat. Cell Biol. 4 (2): 154–9. doi:10.1038/ncb745. PMID 11802162. S2CID 28781777.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000221838 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019518 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9013859-5] Wang X, Kilimann MW (Feb 1997). "Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2". FEBS Lett. 402 (1): 57–61. doi: 10.1016/S0014-5793(96)01500-1 . PMID 9013859. S2CID 81844290.

[pmid10066790-6] Dell'Angelica EC, Mullins C, Bonifacino JS (Apr 1999). "AP-4, a novel protein complex related to clathrin adaptors". J Biol Chem. 274 (11): 7278–85. doi: 10.1074/jbc.274.11.7278 . PMID 10066790.

[entrez-7] 1 2 "Entrez Gene: AP4M1 adaptor-related protein complex 4, mu 1 subunit".

[pmid10436028-8] Hirst J, Bright NA, Rous B, Robinson MS (August 1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell. 10 (8): 2787–802. doi:10.1091/mbc.10.8.2787. PMC 25515 . PMID 10436028.

[pmid21620353-9] Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck G, Ekici A, Brockschmidt FF, Nöthen MM, Munnich A, Strom TM, Reis A, Colleaux L (June 2011). "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature". Am. J. Hum. Genet. 88 (6): 788–95. doi:10.1016/j.ajhg.2011.04.019. PMC 3113253 . PMID 21620353.

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