APOL6

APOL6
Identifiers
Aliases	APOL6 , APOL-VI, APOLVI, apolipoprotein L6
External IDs	OMIM: 607256 MGI: 1919189 HomoloGene: 49940 GeneCards: APOL6
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.3 Start 35,648,446 bp [1] End 35,668,404 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D3 Start 76,928,929 bp [2] End 76,941,306 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium pylorus sperm monocyte human penis vena cava cardia palpebral conjunctiva trigeminal ganglion trachea Top expressed in white adipose tissue subcutaneous adipose tissue soleus muscle brown adipose tissue mammary gland skeletal muscle tissue intercostal muscle thoracic diaphragm tibialis anterior muscle gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding Cellular component extracellular region cytoplasm Biological process lipoprotein metabolic process lipid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80830 71939 Ensembl ENSG00000221963 ENSMUSG00000033576 UniProt Q9BWW8 n/a RefSeq (mRNA) NM_030641 NM_001163621 NM_028010 RefSeq (protein) NP_085144 n/a Location (UCSC) Chr 22: 35.65 – 35.67 Mb Chr 15: 76.93 – 76.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene. ^{[5] [6] [7]}

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000221963 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033576 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID   11374903.
6. Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (Jan 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells". Mol Cancer Res. 3 (1): 21–31. doi: 10.1158/1541-7786.21.3.1 . PMID   15671246. S2CID   2545675.
7. "Entrez Gene: APOL6 apolipoprotein L, 6".

External links

• Human APOL6 genome location and APOL6 gene details page in the UCSC Genome Browser .

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Dominguez O, Ashhab Y, Sabater L, et al. (1999). "Cloning of ARE-containing genes by AU-motif-directed display". Genomics. 54 (2): 278–86. doi:10.1006/geno.1998.5548. PMID   9828130.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.