ARF5

Last updated
ARF5
Protein ARF5 PDB 1z6x.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARF5 , ADP ribosylation factor 5
External IDs OMIM: 103188; MGI: 99434; HomoloGene: 129625; GeneCards: ARF5; OMA:ARF5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001662

NM_007480

RefSeq (protein)

NP_001653

NP_031506

Location (UCSC) Chr 7: 127.59 – 127.59 Mb Chr 6: 28.42 – 28.43 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene. [5] [6]

Contents

ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene spans approximately 3.2kb of genomic DNA and contains six exons and five introns. [6]

Interactions

ARF5 has been shown to interact with ARFIP2. [7] [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000004059 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020440 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tsuchiya M, Price SR, Tsai SC, Moss J, Vaughan M (March 1991). "Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells". J Biol Chem. 266 (5): 2772–7. doi: 10.1016/S0021-9258(18)49913-9 . PMID   1993656.
  6. 1 2 "Entrez Gene: ARF5 ADP-ribosylation factor 5".
  7. Kanoh, H; Williger B T; Exton J H (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J. Biol. Chem. 272 (9). UNITED STATES: 5421–9. doi: 10.1074/jbc.272.9.5421 . ISSN   0021-9258. PMID   9038142.
  8. Shin, O H; Exton J H (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. 285 (5). United States: 1267–73. doi:10.1006/bbrc.2001.5330. ISSN   0006-291X. PMID   11478794.

Further reading