ARFIP2

Last updated
ARFIP2
Protein ARFIP2 PDB 1i49.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARFIP2 , POR1, ADP ribosylation factor interacting protein 2
External IDs OMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Orthologs
SpeciesHumanMouse
Entrez

23647

76932

Ensembl

ENSG00000132254

ENSMUSG00000030881

UniProt

P53365

Q8K221

RefSeq (mRNA)

NM_001242854
NM_001242855
NM_001242856
NM_012402

NM_029802

RefSeq (protein)

NP_084078

Location (UCSC) Chr 11: 6.47 – 6.48 Mb Chr 7: 105.28 – 105.29 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene. [5] [6] [7]

Interactions

ARFIP2 has been shown to interact with Arf6, [8] [9] ARF3, [6] ARF5 [6] [9] and RAC1. [5] [9] [10]

Related Research Articles

<span class="mw-page-title-main">ARF6</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

<span class="mw-page-title-main">ADP ribosylation factor</span> Group of proteins

ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling.

<span class="mw-page-title-main">RAC1</span> Protein-coding gene in the species Homo sapiens

Rac1, also known as Ras-related C3 botulinum toxin substrate 1, is a protein found in human cells. It is encoded by the RAC1 gene. This gene can produce a variety of alternatively spliced versions of the Rac1 protein, which appear to carry out different functions.

<span class="mw-page-title-main">ARF1</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

<span class="mw-page-title-main">GGA1</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.

<span class="mw-page-title-main">GGA3</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.

<span class="mw-page-title-main">RAC2</span> Protein-coding gene in the species Homo sapiens

Rac2 is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RAC2.

<span class="mw-page-title-main">CYTH2</span> Protein-coding gene in the species Homo sapiens

Cytohesin-2 is a protein that in humans is encoded by the CYTH2 gene.

<span class="mw-page-title-main">CYTH1</span> Protein-coding gene in the species Homo sapiens

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

<span class="mw-page-title-main">GIT2</span> Protein-coding gene in humans

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.

<span class="mw-page-title-main">ARF3</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.

<span class="mw-page-title-main">GOLGA4</span> Protein-coding gene in the species Homo sapiens

Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.

<span class="mw-page-title-main">ARF5</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

<span class="mw-page-title-main">ARF4</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

<span class="mw-page-title-main">ARL1</span> Protein-coding gene in humans

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.

<span class="mw-page-title-main">ARL2</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.

<span class="mw-page-title-main">ARL6</span> Mammalian protein found in Homo sapiens

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

<span class="mw-page-title-main">DDEF2</span> Protein-coding gene in the species Homo sapiens

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.

<span class="mw-page-title-main">ARFIP1</span> Protein-coding gene in the species Homo sapiens

Arfaptin-1 is a protein that in humans is encoded by the ARFIP1 gene.

<span class="mw-page-title-main">Arfaptin</span>

In molecular biology, the arfaptin domain is a protein domain which interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Van Aelst L, Joneson T, Bar-Sagi D (August 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC   452058 . PMID   8670882.
  6. 1 2 3 Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID   9038142.
  7. ↑ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
  8. ↑ D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC   1170175 . PMID   9312003.
  9. 1 2 3 Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID   11478794.
  10. ↑ Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID   11346801. S2CID   4324211.

Further reading

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