AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene. [5] [6]
AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene. [5] [6]
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [6]
Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.
G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.
Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.
Collagen alpha-3(IV) chain is a protein that in humans is encoded by the COL4A3 gene.
Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the PTPRF gene.
Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.
Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.
U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene. This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
Melanoma-associated antigen 3 (MAGE-A3) is a protein that in humans is encoded by the MAGEA3 gene.
Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.
HMG-box transcription factor 1, also known as HBP1, is a human protein.
Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.
Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.
AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.
Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2 gene.
40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.
EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene.
Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene.
Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.
Synaptonemal complex protein 1 is a protein involved in the synaptonemal complex during meiosis, that in humans is encoded by the SYCP1 gene.
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