ARIH1

ARIH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WD2, 2M9Y, 4KBL, 4KC9
Identifiers
Aliases	ARIH1 , ARI, HARI, HHARI, UBCH7BP, ariadne RBR E3 ubiquitin protein ligase 1
External IDs	OMIM: 605624 MGI: 1344363 HomoloGene: 111871 GeneCards: ARIH1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	72,602,987 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	59,393,901 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sural nerve; ; ganglionic eminence; ; stromal cell of endometrium; ; Achilles tendon; ; gastrocnemius muscle; ; popliteal artery; ; skin of abdomen; ; internal globus pallidus; ; human penis;
	Top expressed in
	secondary oocyte; ; seminiferous tubule; ; extensor digitorum longus muscle; ; spermatid; ; plantaris muscle; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; ankle; ; digastric muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-like protein transferase activity ; protein binding ; metal ion binding ; ubiquitin protein ligase activity ; ubiquitin protein ligase binding ; ubiquitin-protein transferase activity ; transferase activity ; ubiquitin conjugating enzyme binding ; zinc ion binding ;
Cellular component	cytoplasm ; ubiquitin ligase complex ; cytosol ; nucleus ; Cajal body ; nuclear body ; SCF ubiquitin ligase complex ; Cul2-RING ubiquitin ligase complex ; Cul3-RING ubiquitin ligase complex ; Cul4A-RING E3 ubiquitin ligase complex ; Lewy body ;
Biological process	protein polyubiquitination ; positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; protein ubiquitination ; ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	25820
	23806
	ENSG00000166233
	ENSMUSG00000025234
	Q9Y4X5
	Q9Z1K5
	NM_005744
	NM_019927
	NP_005735
	NP_064311
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 25, 2024

Protein ariadne-1 homolog is a protein that in humans is encoded by the ARIH1 gene.^[5]^[6]

Interactions

ARIH1 has been shown to interact with:

EIF4E2,^[7] and
UBE2L3.^[5]^[7]^[8]

Related Research Articles

Ubiquitin is a small regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ubiquitously. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A.

SUMO-conjugating enzyme UBC9 is an enzyme that in humans is encoded by the UBE2I gene. It is also sometimes referred to as "ubiquitin conjugating enzyme E2I" or "ubiquitin carrier protein 9", even though these names do not accurately describe its function.

Ubiquitin-conjugating enzyme E2 L3 (UBE2L3), also called UBCH7, is a protein that in humans is encoded by the UBE2L3 gene. As an E2 enzyme, UBE2L3 participates in ubiquitination to target proteins for degradation. The role of UBE2L3 in the ubiquitination of the NF-κB precursor implicated it in various major autoimmune diseases, including rheumatoid arthritis (RA), celiac disease, Crohn's disease (CD), and systemic lupus erythematosus.

Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.

Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.

Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene. It belongs to the eukaryotic translation initiation factor 4E family.

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.

Cullin-9 is a protein that in humans is encoded by the CUL9 gene.

Ubiquitin-conjugating enzyme E2 E2 is a protein that in humans is encoded by the UBE2E2 gene.

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166233 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025234 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (November 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi: 10.1074/jbc.274.43.30963 . PMID 10521492.
↑ "Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)".
1 2 Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/s0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.
↑ Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (June 2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi: 10.1074/jbc.M011028200 . PMID 11278816.

External links

Human ARIH1 genome location and ARIH1 gene details page in the UCSC Genome Browser .

Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–44. doi:10.1093/genetics/155.3.1231. PMC 1461160 . PMID 10880484.
Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45): 35224–32. doi: 10.1074/jbc.M003329200 . PMID 10926929.
Tan NG, Ardley HC, Rose SA, Leek JP, Markham AF, Robinson PA (2001). "Characterisation of the human and mouse orthologues of the Drosophila ariadne gene". Cytogenet. Cell Genet. 90 (3–4): 242–5. doi:10.1159/000056780. PMID 11124525. S2CID 12113119.
Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi: 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H . PMID 11124703. S2CID 21397515.
Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi: 10.1074/jbc.M011028200 . PMID 11278816.
Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289 . PMID 12234920.
Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.
Capili AD, Edghill EL, Wu K, Borden KL (2004). "Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING". J. Mol. Biol. 340 (5): 1117–29. doi:10.1016/j.jmb.2004.05.035. PMID 15236971.
Parelkar SS, Cadena JG, Kim C, Wang Z, Sugal R, Bentley B, Moral L, Ardley HC, Schwartz LM (2012). "The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies". J. Mol. Neurosci. 46 (1): 109–21. doi:10.1007/s12031-011-9535-1. PMID 21590270. S2CID 17276111.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166233 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025234 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10521492-5] 1 2 Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (November 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi: 10.1074/jbc.274.43.30963 . PMID 10521492.

[entrez-6] "Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)".

[pmid14623119-7] 1 2 Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/s0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.

[pmid11278816-8] Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (June 2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi: 10.1074/jbc.M011028200 . PMID 11278816.

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ARIH1

Contents

Interactions

Related Research Articles

References

External links

Further reading