ARIH1

ARIH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WD2, 2M9Y, 4KBL, 4KC9
Identifiers
Aliases	ARIH1 , ARI, HARI, HHARI, UBCH7BP, ariadne RBR E3 ubiquitin protein ligase 1
External IDs	OMIM: 605624; MGI: 1344363; HomoloGene: 111871; GeneCards: ARIH1; OMA:ARIH1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q24.1 Start 72,474,330 bp [1] End 72,602,987 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 59,295,541 bp [2] End 59,393,901 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte left testis right testis ventricular zone sural nerve ganglionic eminence epithelium of colon stromal cell of endometrium muscle of thigh Achilles tendon Top expressed in zygote secondary oocyte seminiferous tubule extensor digitorum longus muscle spermatid plantaris muscle neural layer of retina triceps brachii muscle tail of embryo temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-like protein transferase activity protein binding metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase binding ubiquitin-protein transferase activity transferase activity ubiquitin conjugating enzyme binding zinc ion binding Cellular component cytoplasm ubiquitin ligase complex cytosol nucleus Cajal body nuclear body SCF ubiquitin ligase complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex Lewy body Biological process protein polyubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25820 23806 Ensembl ENSG00000166233 ENSMUSG00000025234 UniProt Q9Y4X5 Q9Z1K5 RefSeq (mRNA) NM_005744 NM_019927 RefSeq (protein) NP_005735 NP_064311 Location (UCSC) Chr 15: 72.47 – 72.6 Mb Chr 9: 59.3 – 59.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein ariadne-1 homolog is a protein that in humans is encoded by the ARIH1 gene. ^{[5] [6]}

Interactions

ARIH1 has been shown to interact with:

• EIF4E2, ^[7] and
• UBE2L3. ^{[5] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000166233 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025234 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (November 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi: 10.1074/jbc.274.43.30963 . PMID   10521492.
6. "Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)".
7. Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. Bibcode:2003FEBSL.554..501T. doi:10.1016/s0014-5793(03)01235-3. PMID   14623119. S2CID   25441190.
8. Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (June 2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi: 10.1074/jbc.M011028200 . PMID   11278816.

External links

• Human ARIH1 genome location and ARIH1 gene details page in the UCSC Genome Browser .

Further reading

• Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–44. doi:10.1093/genetics/155.3.1231. PMC   1461160 . PMID   10880484.
• Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45): 35224–32. doi: 10.1074/jbc.M003329200 . PMID   10926929.
• Tan NG, Ardley HC, Rose SA, Leek JP, Markham AF, Robinson PA (2001). "Characterisation of the human and mouse orthologues of the Drosophila ariadne gene". Cytogenet. Cell Genet. 90 (3–4): 242–5. doi:10.1159/000056780. PMID   11124525. S2CID   12113119.
• Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi: 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H . PMID   11124703. S2CID   21397515.
• Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi: 10.1074/jbc.M011028200 . PMID   11278816.
• Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC   126289 . PMID   12234920.
• Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. Bibcode:2003FEBSL.554..501T. doi:10.1016/S0014-5793(03)01235-3. PMID   14623119. S2CID   25441190.
• Capili AD, Edghill EL, Wu K, Borden KL (2004). "Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING". J. Mol. Biol. 340 (5): 1117–29. doi:10.1016/j.jmb.2004.05.035. PMID   15236971.
• Parelkar SS, Cadena JG, Kim C, Wang Z, Sugal R, Bentley B, Moral L, Ardley HC, Schwartz LM (2012). "The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies". J. Mol. Neurosci. 46 (1): 109–21. doi:10.1007/s12031-011-9535-1. PMID   21590270. S2CID   17276111.