EIF4E2

EIF4E2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JGB, 2JGC
Identifiers
Aliases	EIF4E2 , 4E-LP, 4EHP, EIF4EL3, IF4e, eukaryotic translation initiation factor 4E family member 2, h4EHP
External IDs	OMIM: 605895 MGI: 1914440 HomoloGene: 128466 GeneCards: EIF4E2
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.1 Start 232,550,659 bp [1] End 232,583,644 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C5 Start 87,141,636 bp [2] End 87,168,210 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte sural nerve Achilles tendon gastrocnemius muscle rectum islet of Langerhans amniotic fluid sperm stromal cell of endometrium smooth muscle tissue Top expressed in internal carotid artery external carotid artery fossa condyle yolk sac primitive streak seminal vesicula Paneth cell vas deferens hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA cap binding translation factor activity, RNA binding protein binding translation initiation factor activity ubiquitin protein ligase binding RNA binding RNA 7-methylguanosine cap binding Cellular component cytoplasm cytosol mRNA cap binding complex eukaryotic translation initiation factor 4F complex Biological process translational initiation negative regulation of translation in utero embryonic development protein biosynthesis regulation of translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9470 26987 Ensembl ENSG00000135930 ENSMUSG00000026254 UniProt O60573 Q8BMB3 RefSeq (mRNA) NM_001276336 NM_001276337 NM_001282958 NM_004846 NM_001330201 NM_001330202 NM_001330203 NM_001039169 NM_001039170 NM_023314 NM_001347083 RefSeq (protein) NP_001263265 NP_001263266 NP_001269887 NP_001317130 NP_001317131 NP_001317132 NP_004837 NP_001034258 NP_001034259 NP_001334012 NP_075803 Location (UCSC) Chr 2: 232.55 – 232.58 Mb Chr 1: 87.14 – 87.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene. ^{[5] [6] [7] [8]} It belongs to the eukaryotic translation initiation factor 4E family.

Interactions

EIF4E2 has been shown to interact with ARIH1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000135930 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026254 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, et al. (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–8180. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC   20949 . PMID   9653160.
6. Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, et al. (May 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". The Journal of Biological Chemistry. 273 (21): 13104–13109. doi: 10.1074/jbc.273.21.13104 . PMID   9582349.
7. "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2".
8. Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, et al. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development". Molecular and Cellular Biology. 32 (17): 3585–3593. doi:10.1128/MCB.00455-12. PMC   3422012 . PMID   22751931.
9. Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Letters. 554 (3): 501–504. doi:10.1016/S0014-5793(03)01235-3. PMID   14623119. S2CID   25441190.

Further reading

• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Letters. 554 (3): 501–504. doi:10.1016/S0014-5793(03)01235-3. PMID   14623119. S2CID   25441190.
• Tee AR, Tee JA, Blenis J (April 2004). "Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1". FEBS Letters. 564 (1–2): 58–62. doi:10.1016/S0014-5793(04)00313-8. PMID   15094042. S2CID   32997726.
• Joshi B, Cameron A, Jagus R (June 2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–2203. doi: 10.1111/j.1432-1033.2004.04149.x . PMID   15153109.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Okumura F, Zou W, Zhang DE (February 2007). "ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP". Genes & Development. 21 (3): 255–260. doi:10.1101/gad.1521607. PMC   1785121 . PMID   17289916.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD (May 2007). "Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms". Journal of Molecular Biology. 368 (3): 691–705. doi:10.1016/j.jmb.2007.02.019. PMID   17368478.
• Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, Darzynkiewicz E (May 2007). "Weak binding affinity of human 4EHP for mRNA cap analogs". RNA. 13 (5): 691–697. doi:10.1261/rna.453107. PMC   1852817 . PMID   17369309.

External links

• Overview of all the structural information available in the PDB for UniProt : O60573 (Eukaryotic translation initiation factor 4E type 2) at the PDBe-KB .