40S ribosomal protein S11

RPS11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS11 , S11, ribosomal protein S11
External IDs	OMIM: 180471 MGI: 1351329 HomoloGene: 88443 GeneCards: RPS11
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.33 Start 49,496,365 bp [1] End 49,499,708 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B3 Start 44,771,803 bp [2] End 44,773,863 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence urethra human penis superficial temporal artery nipple caput epididymis canal of the cervix germinal epithelium lymph node thymus Top expressed in ganglionic eminence blastocyst thymus morula zone of skin ileum spleen yolk sac lung esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding structural constituent of ribosome protein binding RNA binding Cellular component cytoplasm cytosol ribosome focal adhesion intracellular anatomical structure nucleolus extracellular exosome nucleoplasm extracellular matrix membrane cytosolic small ribosomal subunit Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing osteoblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6205 27207 Ensembl ENSG00000142534 ENSMUSG00000003429 UniProt P62280 P62281 RefSeq (mRNA) NM_001015 NM_013725 RefSeq (protein) NP_001006 NP_038753 Location (UCSC) Chr 19: 49.5 – 49.5 Mb Chr 7: 44.77 – 44.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S11 is a protein that in humans is encoded by the RPS11 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S17) is thought to be involved in the recognition of termination codons. This gene is co-transcribed with a small nucleolar RNA gene, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000142534 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003429 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics. 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID   1577483.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPS11 ribosomal protein S11".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Ferrari S, Manfredini R, Tagliafico E, et al. (1990). "Noncoordinated expression of S6, S11, and S14 ribosomal protein genes in leukemic blast cells". Cancer Res. 50 (18): 5825–8. PMID   1697501.
• Lott JB, Mackie GA (1988). "Sequence of a cloned cDNA encoding human ribosomal protein S11". Nucleic Acids Res. 16 (3): 1205. doi:10.1093/nar/16.3.1205. PMC   334755 . PMID   3267208.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Higa S, Yoshihama M, Tanaka T, Kenmochi N (2000). "Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome". Gene. 240 (2): 371–7. doi:10.1016/S0378-1119(99)00429-1. PMID   10580157. S2CID   25643638.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Overview of all the structural information available in the PDB for UniProt : P62280 (40S ribosomal protein S11) at the PDBe-KB .