40S ribosomal protein S5

RPS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 4V5Z, 5FLX, 4D61, 4UJC,%%s4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5A2Q, 4V6X, 4UJD, 3J7P, 5AJ0, 4KZZ, 4UG0, 4UJE, 4UJC, 5FLX
Identifiers
Aliases	RPS5 , S5, ribosomal protein S5
External IDs	OMIM: 603630 MGI: 1097682 HomoloGene: 783 GeneCards: RPS5
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.43 Start 58,386,400 bp [1] End 58,394,806 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A1 Start 12,656,217 bp [2] End 12,660,613 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vulva spongy bone human penis oral cavity superficial temporal artery right uterine tube skin of abdomen nipple caput epididymis body of pancreas Top expressed in maxillary prominence internal carotid artery somite medial ganglionic eminence external carotid artery cervix molar abdominal wall dermis endocardial cushion More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding mRNA binding RNA binding rRNA binding Cellular component cytosol ribosome membrane focal adhesion small ribosomal subunit extracellular exosome extracellular matrix nucleoplasm cytosolic small ribosomal subunit ribonucleoprotein complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation regulation of translational fidelity nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis ribosomal small subunit assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6193 20103 Ensembl ENSG00000083845 ENSMUSG00000012848 UniProt P46782 P97461 RefSeq (mRNA) NM_001009 NM_009095 RefSeq (protein) NP_001000 NP_001000.2 NP_033121 Location (UCSC) Chr 19: 58.39 – 58.39 Mb Chr 7: 12.66 – 12.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, in eukaryotes , consist of a small 40S subunit and a large 60S subunit (whereas prokaryotic ribosomes are 70 Svedberg units, composed of 50S and 30S subunits). They are located in the cytoplasm. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the eukaryotic 40S subunit. The protein belongs to the S7P family of ribosomal proteins. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000083845 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000012848 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID   7772601.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPS5 ribosomal protein S5".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon". Biochim. Biophys. Acta. 1173 (3): 273–82. doi:10.1016/0167-4781(93)90124-v. PMID   8318536.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002). "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics. 17 (12): 1152–7. doi: 10.1093/bioinformatics/17.12.1152 . PMID   11751223.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malygin A, Baranovskaya O, Ivanov A, Karpova G (2003). "Expression and purification of human ribosomal proteins S3, S5, S10, S19, and S26". Protein Expr. Purif. 28 (1): 57–62. doi:10.1016/S1046-5928(02)00652-6. PMID   12651107.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.

External links

• Overview of all the structural information available in the PDB for UniProt : P46782 (40S ribosomal protein S5) at the PDBe-KB .