40S ribosomal protein S3a

Last updated
RPS3A
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RPS3A , FTE1, MFTL, S3A, ribosomal protein S3A
External IDs OMIM: 180478; MGI: 1202063; HomoloGene: 133575; GeneCards: RPS3A; OMA:RPS3A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267699
NM_001006

NM_016959

RefSeq (protein)

NP_000997
NP_001254628

NP_058655

Location (UCSC) Chr 4: 151.1 – 151.1 Mb Chr 3: 86.05 – 86.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S3a is a protein that in humans is encoded by the RPS3A gene. [5] [6] [7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. Transcript variants utilizing alternative transcription start sites have been described. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [7]

Interactions

RPS3A has been shown to interact with DNA damage-inducible transcript 3. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000145425 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028081 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nolte D, Taimor G, Kalff-Suske M, Seifart KH (July 1996). "The human S3a ribosomal protein: sequence, location and cell-free transcription of the functional gene". Gene. 169 (2): 179–85. doi:10.1016/0378-1119(95)00708-3. PMID   8647443.
  6. Metspalu A, Rebane A, Hoth S, Pooga M, Stahl J, Kruppa J (November 1992). "Human ribosomal protein S3a: cloning of the cDNA and primary structure of the protein". Gene. 119 (2): 313–6. doi:10.1016/0378-1119(92)90289-2. PMID   1398113.
  7. 1 2 "Entrez Gene: RPS3A ribosomal protein S3A".
  8. Cui, K; Coutts M; Stahl J; Sytkowski A J (March 2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis". J. Biol. Chem. 275 (11). UNITED STATES: 7591–6. doi: 10.1074/jbc.275.11.7591 . ISSN   0021-9258. PMID   10713066.

Further reading