60S ribosomal protein L21

RPL21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL21 , HYPT12, L21, ribosomal protein L21
External IDs	OMIM: 603636 MGI: 1278340 HomoloGene: 128048 GeneCards: RPL21
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q12.2 Start 27,251,362 bp [1] End 27,256,691 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G3 Start 146,769,700 bp [2] End 146,773,842 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence endometrium lymph node monocyte superior frontal gyrus ovary islet of Langerhans bone marrow thymus Top expressed in ovary urinary bladder ganglionic eminence mirror zone of skin uterus adrenal gland esophagus ileum thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic large ribosomal subunit cytoplasm endoplasmic reticulum Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6144 19933 Ensembl ENSG00000122026 ENSMUSG00000041453 UniProt P46778 O09167 Q9CQM8 RefSeq (mRNA) NM_000982 NM_019647 RefSeq (protein) NP_000973 NP_062621 Location (UCSC) Chr 13: 27.25 – 27.26 Mb Chr 5: 146.77 – 146.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

Clinical relevance

Mutations in the RPL21 gene result in Hypotrichosis simplex of the scalp. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000122026 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041453 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakamichi NN, Kao FT, Wasmuth J, Roufa DJ (Jul 1986). "Ribosomal protein gene sequences map to human chromosomes 5, 8, and 17". Somat Cell Mol Genet. 12 (3): 225–36. doi:10.1007/BF01570781. PMID   3459254. S2CID   20534231.
6. Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID   7772601.
7. "Entrez Gene: RPL21 ribosomal protein L21".
8. Zhou C, Zang D, Jin Y, et al. (March 2011). "Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex". Human Mutation. 32 (7): 710–4. doi: 10.1002/humu.21503 . PMID   21412954. S2CID   3715445.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID   7951316. S2CID   11075629.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi: 10.1126/science.1058040 . PMID   11181995.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID   11401437.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002). "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics. 17 (12): 1152–7. doi: 10.1093/bioinformatics/17.12.1152 . PMID   11751223.
• Zhang W, Hawse J, Huang Q, et al. (2002). "Decreased expression of ribosomal proteins in human age-related cataract". Invest. Ophthalmol. Vis. Sci. 43 (1): 198–204. PMC   2831404 . PMID   11773032.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID   12962325. S2CID   10710245.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Overview of all the structural information available in the PDB for UniProt : P46778 (60S ribosomal protein L21) at the PDBe-KB .