Mitochondrial ribosomal protein L41

MRPL41
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL41 , BMRP, MRP-L27, MRPL27, RPML27, PIG3, Mitochondrial ribosomal protein L41
External IDs	OMIM: 611846 MGI: 1333816 HomoloGene: 13036 GeneCards: MRPL41
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 137,551,879 bp [1] End 137,552,555 bp [1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural constituent of ribosome • GO:0001948 protein binding • RNA binding Cellular component • mitochondrial inner membrane • ribosome • mitochondrion • mitochondrial large ribosomal subunit • ribonucleoprotein complex Biological process • cell cycle • mitochondrial translational elongation • mitochondrial translational termination • protein biosynthesis • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64975	107733
Ensembl	ENSG00000182154	ENSMUSG00000036850
UniProt	Q8IXM3	Q9CQN7
RefSeq (mRNA)	NM_032477	NM_001031808
RefSeq (protein)	NP_115866	NP_001026978
Location (UCSC)	Chr 9: 137.55 – 137.55 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene. ^{[4] [5]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000182154 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
5. "Entrez Gene: MRPL41 mitochondrial ribosomal protein L41".

Further reading

• Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 273 (52): 34828–36. doi: 10.1074/jbc.273.52.34828 . PMID   9857009.
• Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–69. doi: 10.1074/jbc.M106510200 . PMID   11551941.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Chintharlapalli SR, Jasti M, Malladi S, et al. (2005). "BMRP is a Bcl-2 binding protein that induces apoptosis". J. Cell. Biochem. 94 (3): 611–26. doi:10.1002/jcb.20292. PMID   15547950. S2CID   23940695.
• Yoo YA, Kim MJ, Park JK, et al. (2005). "Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1". Mol. Cell. Biol. 25 (15): 6603–16. doi:10.1128/MCB.25.15.6603-6616.2005. PMC   1190350 . PMID   16024796.
• Kim MJ, Yoo YA, Kim HJ, et al. (2006). "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1)". Biochem. Biophys. Res. Commun. 338 (2): 1179–84. doi:10.1016/j.bbrc.2005.10.064. PMID   16256947.