EIF3H

EIF3H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J8B, 3J8C
Identifiers
Aliases	EIF3H , EIF3S3, eIF3-gamma, eIF3-p40, eukaryotic translation initiation factor 3 subunit H
External IDs	OMIM: 603912 MGI: 1915385 HomoloGene: 2785 GeneCards: EIF3H
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q23.3-q24.11 Start 116,642,130 bp [1] End 116,766,925 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 C Start 51,649,954 bp [2] End 51,728,919 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence parotid gland monocyte canal of the cervix lymph node body of pancreas parietal pleura gastric mucosa tibia rectum Top expressed in yolk sac lip morula ankle joint superior frontal gyrus spermatid spermatocyte thymus esophagus cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding translation initiation factor activity RNA binding metallopeptidase activity Cellular component cytoplasm cytosol eukaryotic translation initiation factor 3 complex eukaryotic translation initiation factor 3 complex, eIF3m extracellular exosome membrane eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex polysomal ribosome Biological process translational initiation regulation of translational initiation protein biosynthesis formation of cytoplasmic translation initiation complex cytoplasmic translational initiation proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8667 68135 Ensembl ENSG00000147677 ENSMUSG00000022312 UniProt O15372 Q91WK2 RefSeq (mRNA) NM_003756 NM_080635 RefSeq (protein) NP_003747 NP_542366 Location (UCSC) Chr 8: 116.64 – 116.77 Mb Chr 15: 51.65 – 51.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene. ^{[5] [6]}

Interactions

eIF3h has been shown to interact with eIF3a. ^{[7] [8] [9]}

See also

• Eukaryotic initiation factor 3 (eIF3)

References

1. GRCh38: Ensembl release 89: ENSG00000147677 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022312 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW (Nov 1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly". J. Biol. Chem. 272 (43): 27042–52. doi: 10.1074/jbc.272.43.27042 . PMID   9341143.
6. "Entrez Gene: EIF3S3 eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa".
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
8. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi: 10.1046/j.1432-1033.2003.03807.x . PMID   14519125.
9. Block KL, Vornlocher HP, Hershey JW (Nov 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi: 10.1074/jbc.273.48.31901 . PMID   9822659.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Asano K, Kinzy TG, Merrick WC, Hershey JW (1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". J. Biol. Chem. 272 (2): 1101–9. doi: 10.1074/jbc.272.2.1101 . PMID   8995409.
• Méthot N, Rom E, Olsen H, Sonenberg N (1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi: 10.1074/jbc.272.2.1110 . PMID   8995410.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Block KL, Vornlocher HP, Hershey JW (1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi: 10.1074/jbc.273.48.31901 . PMID   9822659.
• Saramäki O, Willi N, Bratt O, Gasser TC, Koivisto P, Nupponen NN, Bubendorf L, Visakorpi T (2001). "Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer". Am. J. Pathol. 159 (6): 2089–94. doi:10.1016/S0002-9440(10)63060-X. PMC   1850612 . PMID   11733359.
• Morris JA, Kandpal G, Ma L, Austin CP (2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi: 10.1093/hmg/ddg162 . PMID   12812986.
• Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi: 10.1046/j.1432-1033.2003.03807.x . PMID   14519125.
• Okamoto H, Yasui K, Zhao C, Arii S, Inazawa J (2003). "PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas". Hepatology. 38 (5): 1242–9. doi: 10.1053/jhep.2003.50457 . PMID   14578863. S2CID   21888517.
• Savinainen KJ, Linja MJ, Saramäki OR, Tammela TL, Chang GT, Brinkmann AO, Visakorpi T (2004). "Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer". Br. J. Cancer. 90 (5): 1041–6. doi:10.1038/sj.bjc.6601648. PMC   2409619 . PMID   14997205.
• Savinainen KJ, Helenius MA, Lehtonen HJ, Visakorpi T (2006). "Overexpression of EIF3S3 promotes cancer cell growth". Prostate. 66 (11): 1144–50. doi:10.1002/pros.20452. PMID   16652384. S2CID   2281409.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• Overview of all the structural information available in the PDB for UniProt : O15372 (Eukaryotic translation initiation factor 3 subunit H) at the PDBe-KB .