Mitochondrial ribosomal protein L19

MRPL19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL19 , L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15, mitochondrial ribosomal protein L19
External IDs	OMIM: 611832; MGI: 1926274; HomoloGene: 8851; GeneCards: MRPL19; OMA:MRPL19 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p12 Start 75,646,783 bp [1] End 75,690,851 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 C3|6 35.81 cM Start 81,934,832 bp [2] End 81,942,939 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle right adrenal gland Skeletal muscle tissue of biceps brachii left adrenal gland rectum right adrenal cortex gingival epithelium left adrenal cortex islet of Langerhans muscle of thigh Top expressed in endocardial cushion medullary collecting duct epiblast otic placode migratory enteric neural crest cell blastocyst atrioventricular valve atrium renal corpuscle lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome nuclear membrane intracellular anatomical structure nucleus mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9801 56284 Ensembl ENSG00000115364 ENSMUSG00000030045 UniProt P49406 Q9D338 RefSeq (mRNA) NM_014763 NM_026490 RefSeq (protein) NP_055578 NP_080766 Location (UCSC) Chr 2: 75.65 – 75.69 Mb Chr 6: 81.93 – 81.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene. ^{[5] [6] [7]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000115364 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030045 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, et al. (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
6. Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, et al. (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Human Molecular Genetics. 16 (6): 667–677. doi:10.1093/hmg/ddm009. PMID   17309879.
7. "Entrez Gene: MRPL19 mitochondrial ribosomal protein L19".

Further reading

• Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID   7788527.
• The Sanger Centre, The Washington University Genome Sequencing Cente (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Graack HR, Bryant ML, O'Brien TW (Dec 1999). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–16577. doi:10.1021/bi991543s. PMID   10600119.
• Hoja MR, Wahlestedt C, Höög C (Aug 2000). "A visual intracellular classification strategy for uncharacterized human proteins". Experimental Cell Research. 259 (1): 239–246. doi:10.1006/excr.2000.4948. PMID   10942595.
• Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, et al. (Jun 2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". Journal of Biological Chemistry. 276 (24): 21724–21736. doi: 10.1074/jbc.M100432200 . PMID   11279069.
• Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–480. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.