60S ribosomal protein L39

RPL39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4V5Z, 4D5Y, 3J7O
Identifiers
Aliases	RPL39 , L39, RPL39P42, RPL39_23_1806, ribosomal protein L39
External IDs	OMIM: 300899 MGI: 1914498 HomoloGene: 133571 GeneCards: RPL39
Gene location (Human) Chr. X chromosome (human) [1] Band Xq24 Start 119,786,504 bp [1] End 119,791,630 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A3.3 Start 36,346,173 bp [2] End 36,349,055 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence endometrium skin of abdomen subcutaneous adipose tissue lymph node spleen right adrenal gland rectum right uterine tube vagina Top expressed in yolk sac ganglionic eminence lip esophagus uterus duodenum urinary bladder jejunum bone marrow neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding structural constituent of ribosome Cellular component ribosome cytosol intracellular anatomical structure extracellular space cytosolic large ribosomal subunit polysomal ribosome Biological process SRP-dependent cotranslational protein targeting to membrane innate immune response in mucosa viral transcription nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation protein biosynthesis rRNA processing antimicrobial humoral immune response mediated by antimicrobial peptide cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6170 67248 Ensembl ENSG00000198918 ENSMUSG00000079641 UniProt P62891 P62892 RefSeq (mRNA) NM_001000 NM_026055 RefSeq (protein) NP_000991 NP_080331 Location (UCSC) Chr X: 119.79 – 119.79 Mb Chr X: 36.35 – 36.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L39 is a protein that in humans is encoded by the RPL39 gene. ^{[5] [6]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198918 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079641 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Otsuka S, Tanaka M, Saito S, Yoshimoto K, Itakura M (Sep 1996). "Molecular cloning of a cDNA encoding human ribosomal protein L39". Biochim Biophys Acta. 1308 (2): 119–21. doi:10.1016/0167-4781(96)00106-6. PMID   8764829.
6. "Entrez Gene: RPL39 ribosomal protein L39".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID   11401437.
• Tsui SK, Lee SM, Fung KP, et al. (1997). "Primary structures and sequence analysis of human ribosomal proteins L39 and S27". Biochem. Mol. Biol. Int. 40 (3): 611–6. doi: 10.1080/15216549600201203 . PMID   8908372. S2CID   7909023.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.