Mitochondrial ribosomal protein L39

MRPL39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL39 , C21orf92, L39mt, MRP-L5, MRPL5, PRED22, PRED66, RPML5, MSTP003, mitochondrial ribosomal protein L39, L5mt
External IDs	OMIM: 611845 MGI: 1351620 HomoloGene: 9679 GeneCards: MRPL39
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q21.3 Start 25,585,656 bp [1] End 25,607,517 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C3.3 Start 84,514,464 bp [2] End 84,532,630 bp [2]
RNA expression pattern Bgee Top expressed in oocyte left ventricle Right adrenal gland Achilles tendon gastrocnemius muscle secondary oocyte Left adrenal gland rectum vastus lateralis muscle right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrial large ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54148	27393
Ensembl	ENSG00000154719	ENSMUSG00000022889
UniProt	Q9NYK5	Q9JKF7
RefSeq (mRNA)	NM_017446 NM_080794	NM_017404 NM_001384093 NM_001384095 NM_001384096
RefSeq (protein)	NP_059142 NP_542984	NP_059100 NP_001371022 NP_001371024 NP_001371025
Location (UCSC)	Chr 21: 25.59 – 25.61 Mb	Chr 16: 84.51 – 84.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene. ^{[5] [6]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154719 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022889 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
6. "Entrez Gene: MRPL39 mitochondrial ribosomal protein L39".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• O'Brien TW, Fiesler SE, Denslow ND, et al. (2000). "Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 274 (51): 36043–51. doi: 10.1074/jbc.274.51.36043 . PMID   10593885.
• Spirina O, Bykhovskaya Y, Kajava AV, et al. (2001). "Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing)". Gene. 261 (2): 229–34. doi:10.1016/S0378-1119(00)00504-7. PMID   11167009.
• O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene. 286 (1): 73–9. doi:10.1016/S0378-1119(01)00808-3. PMID   11943462.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.