MRPS24

Last updated
MRPS24
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS24 , MRP-S24, S24mt, bMRP-47, bMRP47, HSPC335, mitochondrial ribosomal protein S24
External IDs OMIM: 611986; MGI: 1928142; HomoloGene: 57043; GeneCards: MRPS24; OMA:MRPS24 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032014

NM_026080
NM_001362871

RefSeq (protein)

NP_114403

NP_080356
NP_001349800

Location (UCSC) Chr 7: 43.87 – 43.87 Mb Chr 11: 5.65 – 5.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S24, mitochondrial is a protein that in humans is encoded by the MRPS24 gene. [5] [6] [7]

Contents

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000062582 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020477 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Xu L, He GP, Li A, Ro HS (Apr 1994). "Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs". Nucleic Acids Res. 22 (4): 646–55. doi:10.1093/nar/22.4.646. PMC   307856 . PMID   8127713.
  6. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
  7. 1 2 "Entrez Gene: MRPS24 mitochondrial ribosomal protein S24".

Further reading