MRPS24

MRPS24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS24 , MRP-S24, S24mt, bMRP-47, bMRP47, HSPC335, mitochondrial ribosomal protein S24
External IDs	OMIM: 611986 MGI: 1928142 HomoloGene: 57043 GeneCards: MRPS24
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p13 Start 43,866,558 bp [1] End 43,869,893 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 5,653,983 bp [2] End 5,665,680 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle left ventricle Right adrenal gland body of pancreas body of stomach fundus kidney right lobe of liver skeletal muscle tissue prefrontal cortex Top expressed in endocardial cushion lacrimal gland medullary collecting duct renal corpuscle atrioventricular valve facial motor nucleus intercostal muscle Paneth cell Epithelium of stomach internal carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrion mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64951 64660 Ensembl ENSG00000062582 ENSMUSG00000020477 UniProt Q96EL2 Q9CQV5 RefSeq (mRNA) NM_032014 NM_026080 NM_001362871 RefSeq (protein) NP_114403 NP_080356 NP_001349800 Location (UCSC) Chr 7: 43.87 – 43.87 Mb Chr 11: 5.65 – 5.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S24, mitochondrial is a protein that in humans is encoded by the MRPS24 gene. ^{[5] [6] [7]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000062582 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020477 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu L, He GP, Li A, Ro HS (Apr 1994). "Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs". Nucleic Acids Res. 22 (4): 646–55. doi:10.1093/nar/22.4.646. PMC   307856 . PMID   8127713.
6. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
7. "Entrez Gene: MRPS24 mitochondrial ribosomal protein S24".

Further reading

• Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC   20949 . PMID   9653160.
• Koc EC, Burkhart W, Blackburn K, et al. (2000). "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins". J. Biol. Chem. 275 (42): 32585–91. doi: 10.1074/jbc.M003596200 . PMID   10938081.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi: 10.1074/jbc.M103236200 . PMID   11402041.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Overview of all the structural information available in the PDB for UniProt : Q96EL2 (28S ribosomal protein S24, mitochondrial) at the PDBe-KB .