40S ribosomal protein S26

RPS26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 3J7R, 4D61, 4D5L, 4UJD, 3J7P, 4UJE, 4UJC
Identifiers
Aliases	RPS26 , DBA10, S26, ribosomal protein S26, eS26
External IDs	OMIM: 603701 MGI: 1351628 HomoloGene: 37420 GeneCards: RPS26
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.2 Start 56,041,351 bp [1] End 56,044,697 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D3 Start 128,460,403 bp [2] End 128,462,616 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa right uterine tube anterior pituitary left uterine tube body of pancreas right lung rectum lymph node skin of abdomen body of stomach Top expressed in urinary bladder bone marrow uterus spleen adrenal gland thymus lens lip yolk sac ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding mRNA binding RNA binding cadherin binding Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic small ribosomal subunit small ribosomal subunit extracellular exosome nucleoplasm cytoplasm endoplasmic reticulum rough endoplasmic reticulum polysomal ribosome cytoplasmic side of rough endoplasmic reticulum membrane Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of RNA splicing protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6231 27370 Ensembl ENSG00000197728 ENSMUSG00000025362 UniProt P62854 P62855 RefSeq (mRNA) NM_001029 NM_013765 RefSeq (protein) NP_001020 NP_038793 Location (UCSC) Chr 12: 56.04 – 56.04 Mb Chr 10: 128.46 – 128.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S26 is a protein that in humans is encoded by the RPS26 gene. ^{[5] [6] [7]}

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000197728 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025362 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
6. Filipenko ML, Mishin VP, Suturina IuA, Muravlev AI, Kopantsev EA, Karpova GG, Mertvetsov NP (Aug 1996). "[Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]". Bioorg Khim. 21 (11): 838–44. PMID   8670309.
7. "Entrez Gene: RPS26 ribosomal protein S26".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Filipenko ML, Vladimirov SN, Muravlev AI, et al. (1994). "[Cloning cDNA of human S26 ribosomal protein and determination of its primary structure]". Bioorg. Khim. 20 (6): 644–9. PMID   7945460.
• Vincent S, Marty L, Fort P (1993). "S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues". Nucleic Acids Res. 21 (6): 1498. doi:10.1093/nar/21.6.1498. PMC   309346 . PMID   8464749.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Filipenko ML, Vinichenko NA, Karpova GG, et al. (1998). "Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26". Gene. 211 (2): 287–92. doi:10.1016/S0378-1119(98)00108-5. PMID   9602156.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi: 10.1073/pnas.241522398 . PMC   64988 . PMID   11752456.
• Ivanov AV, Malygin AA, Karpova GG (2002). "[Ribosomal protein binding with the first intron of the human ribosomal protein S26 pre-mRNA stimulates its interaction with proteins extracted from Hela cells]". Mol. Biol. (Mosk.). 36 (3): 503–10. PMID   12068637.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ivanov AV, Malygin AA, Karpova GG (2005). "Human ribosomal protein S26 suppresses the splicing of its pre-mRNA". Biochim. Biophys. Acta. 1727 (2): 134–40. doi:10.1016/j.bbaexp.2004.12.011. PMID   15716004.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells" (PDF). Mol. Cell. Proteomics. 6 (4): 575–88. doi: 10.1074/mcp.M600249-MCP200 . PMID   17220478. S2CID   7203032.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia
• Overview of all the structural information available in the PDB for UniProt : P62854 (40S ribosomal protein S26) at the PDBe-KB .