MRPS6

Last updated
MRPS6
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS6 , C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6
External IDs OMIM: 611973; MGI: 2153111; HomoloGene: 41871; GeneCards: MRPS6; OMA:MRPS6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032476

NM_080456

RefSeq (protein)

NP_115865

NP_536704

Location (UCSC) Chr 21: 34.07 – 34.14 Mb Chr 16: 91.86 – 91.91 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene. [5]

Contents

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000243927 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039680 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MRPS6 mitochondrial ribosomal protein S6".

Further reading