60S ribosomal protein L24

RPL24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0
Identifiers
Aliases	RPL24 , HEL-S-310, L24, ribosomal protein L24
External IDs	OMIM: 604180 MGI: 1915443 HomoloGene: 763 GeneCards: RPL24
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q12.3 Start 101,681,091 bp [1] End 101,686,718 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 C1.1|16 33.74 cM Start 55,786,638 bp [2] End 55,791,798 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon anterior pituitary ganglionic eminence islet of Langerhans thyroid gland corpus callosum left lobe of thyroid gland cerebellar hemisphere canal of the cervix right lobe of thyroid gland Top expressed in morula urinary bladder ganglionic eminence uterus thymus mirror pancreas hypothalamus lip adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of ribosome cadherin binding RNA binding Cellular component cytoplasm cytosol ribosome membrane cytosolic large ribosomal subunit extracellular exosome endoplasmic reticulum polysomal ribosome synapse Biological process assembly of large subunit precursor of preribosome viral transcription mitotic cell cycle checkpoint signaling exit from mitosis SRP-dependent cotranslational protein targeting to membrane retina development in camera-type eye ribosomal large subunit assembly translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay optic nerve development retinal ganglion cell axon guidance rRNA processing protein biosynthesis cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6152 68193 Ensembl ENSG00000114391 ENSMUSG00000098274 UniProt P83731 Q8BP67 RefSeq (mRNA) NM_000986 NM_024218 RefSeq (protein) NP_000977 NP_077180 Location (UCSC) Chr 3: 101.68 – 101.69 Mb Chr 16: 55.79 – 55.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L24 is a protein that in humans is encoded by the RPL24 gene. ^{[5] [6]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from Saccharomyces cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000114391 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000098274 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
6. "Entrez Gene: RPL24 ribosomal protein L24".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID   8012384. S2CID   12847618.
• Johnson KR (1993). "Characterization of cDNA clones encoding the human homologue of Saccharomyces cerevisiae ribosomal protein L30". Gene. 123 (2): 283–5. doi:10.1016/0378-1119(93)90139-T. PMID   8428672.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID   11401437.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID   12962325. S2CID   10710245.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics. 6 (4): 575–88. doi: 10.1074/mcp.M600249-MCP200 . PMID   17220478.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.