EIF1AX

Last updated
EIF1AX
Protein EIF1AX PDB 1d7q.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EIF1AX , EIF1A, EIF1AP1, EIF4C, eIF-1A, eIF-4C, eukaryotic translation initiation factor 1A, X-linked, eukaryotic translation initiation factor 1A X-linked
External IDs OMIM: 300186 MGI: 95298 HomoloGene: 20364 GeneCards: EIF1AX
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001412

NM_010120
NM_001374654

RefSeq (protein)

NP_001403

NP_034250

Location (UCSC) Chr X: 20.12 – 20.14 Mb Chr 18: 46.73 – 46.75 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene. [5] [6] [7] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs. [7]

Contents

Function

eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1. [8]

Clinical significance

Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3. [9] eIF1A is mutated in thyroid cancers. [10]

Interactions

EIF1AX has been shown to interact with IPO13. [11]

See also

Related Research Articles

<span class="mw-page-title-main">RBM8A</span> Protein-coding gene in the species Homo sapiens

RNA-binding protein 8A is a protein that in humans is encoded by the RBM8A gene.

<span class="mw-page-title-main">EIF4G2</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 4 gamma 2 is a protein that in humans is encoded by the EIF4G2 gene.

<span class="mw-page-title-main">Eukaryotic translation initiation factor 4 gamma 1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.

<span class="mw-page-title-main">EIF2S1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.

<span class="mw-page-title-main">EIF3A</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

<span class="mw-page-title-main">MKNK1</span> Protein-coding gene in the species Homo sapiens

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.

<span class="mw-page-title-main">EIF4G3</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.

<span class="mw-page-title-main">EIF4A1</span> Protein coding gene in Humans

Eukaryotic initiation factor 4A-I is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-dependant RNA helicases, and plays a critical role in the initiation of cap-dependent eukaryotic protein translation as a component of the eIF4F translation initiation complex. eIF4A1 unwinds the secondary structure of RNA within the 5'-UTR of mRNA, a critical step necessary for the recruitment of the 43S preinitiation complex, and thus the translation of protein in eukaryotes. It was first characterized in 1982 by Grifo, et al., who purified it from rabbit reticulocyte lysate.

<span class="mw-page-title-main">EIF4B</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.

<span class="mw-page-title-main">EIF3B</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.

<span class="mw-page-title-main">EIF3H</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.

<span class="mw-page-title-main">EIF5</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

<span class="mw-page-title-main">EIF3F</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a protein that in humans is encoded by the EIF3F gene.

<span class="mw-page-title-main">EIF3D</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

<span class="mw-page-title-main">EIF4ENIF1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.

<span class="mw-page-title-main">EIF5B</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.

<span class="mw-page-title-main">EIF1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.

<span class="mw-page-title-main">EIF1AY</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.

<span class="mw-page-title-main">IPO13</span> Protein-coding gene in the species Homo sapiens

Importin-13 is a protein encoded by the IPO13 gene in humans. Importin-13 is a member of the importin-β family of nuclear transport receptors (NTRs) and was first identified as a transport receptor in 2000. According to PSI-blast based secondary structure PREDiction (PSIPRED), importin-13 contains 38 α-helices. Importin-13 accommodates a range of cargoes due to its flexible superhelical structure and a cargo binding and release system that is distinct from other importin-like transport receptors. IPO13 is broadly expressed in a variety of tissues in the human body, including the heart, cornea, fetal lung, brain, endometrial carcinoma, and testes.

Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha, a beta, and a gamma subunit.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000173674 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057561 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Feb 1994). "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing". The Journal of Biological Chemistry. 269 (5): 3212–8. doi: 10.1016/S0021-9258(17)41850-3 . PMID   8106356.
  6. Lahn BT, Page DC (Oct 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID   9381176.
  7. 1 2 "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked".
  8. Fraser, Christopher S. (2015). "Quantitative studies of mRNA recruitment to the eukaryotic ribosome". Biochimie. 114: 58–71. doi:10.1016/j.biochi.2015.02.017. PMC   4458453 . PMID   25742741.
  9. Martin M, Maßhöfer L, Temming P, Rahmann S, Metz C, Bornfeld N, van de Nes J, Klein-Hitpass L, Hinnebusch AG, Horsthemke B, Lohmann DR, Zeschnigk M (Aug 2013). "Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3". Nature Genetics. 45 (8): 933–6. doi:10.1038/ng.2674. PMC   4307600 . PMID   23793026.
  10. Xu, Yichen; Ruggero, Davide (2020-03-09). "The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications". Annual Review of Cancer Biology. 4 (1): 437–457. doi: 10.1146/annurev-cancerbio-030419-033420 . ISSN   2472-3428.
  11. Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (Jul 2001). "Importin 13: a novel mediator of nuclear import and export". The EMBO Journal. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMC   125545 . PMID   11447110.

Further reading