Mitochondrial ribosomal protein L1

Last updated
MRPL1
PBB Protein MRPL11 image.jpg
Identifiers
Aliases MRPL1 , BM022, L1MT, MRP-L1, mitochondrial ribosomal protein L1
External IDs OMIM: 611821; MGI: 2137202; HomoloGene: 41355; GeneCards: MRPL1; OMA:MRPL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020236

NM_001039084
NM_053158

RefSeq (protein)

NP_064621

NP_001034173
NP_444388

Location (UCSC) Chr 4: 77.86 – 77.95 Mb Chr 5: 96.36 – 96.41 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene. [5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169288 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029486 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MRPL1 mitochondrial ribosomal protein L1".

Further reading