MRPS11

MRPS11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS11 , HCC-2, MRP-S11, S11mt, mitochondrial ribosomal protein S11
External IDs	OMIM: 611977 MGI: 1915244 HomoloGene: 32554 GeneCards: MRPS11
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q25.3 Start 88,467,453 bp [1] End 88,480,776 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 D2 Start 78,432,867 bp [2] End 78,442,737 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle Left adrenal gland Right adrenal gland right lobe of thyroid gland gastrocnemius muscle right lobe of liver left lobe of thyroid gland prefrontal cortex anterior pituitary stromal cell of endometrium Top expressed in spermatid spermatocyte morula adrenal gland sternocleidomastoid muscle yolk sac medial ganglionic eminence temporal muscle digastric muscle triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome mRNA 5'-UTR binding small ribosomal subunit rRNA binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial small ribosomal subunit Biological process ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64963 67994 Ensembl ENSG00000181991 ENSMUSG00000030611 UniProt P82912 Q9DCA2 RefSeq (mRNA) NM_022839 NM_176805 NM_001321970 NM_001321972 NM_001321973 NM_001321974 NM_001321976 NM_026498 NM_001360702 RefSeq (protein) NP_001308899 NP_001308901 NP_001308902 NP_001308903 NP_001308905 NP_073750 NP_789775 n/a Location (UCSC) Chr 15: 88.47 – 88.48 Mb Chr 7: 78.43 – 78.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S11, mitochondrial is a protein that in humans is encoded by the MRPS11 gene. ^{[5] [6]}

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000181991 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030611 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (Aug 2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J Biol Chem. 276 (35): 33181–95. doi: 10.1074/jbc.M103236200 . PMID   11402041.
6. "Entrez Gene: MRPS11 mitochondrial ribosomal protein S11".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Ishiguchi H, Izumi H, Torigoe T, et al. (2004). "ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA". Int. J. Cancer. 111 (6): 900–9. doi:10.1002/ijc.20358. PMID   15300802. S2CID   37308382.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• Overview of all the structural information available in the PDB for UniProt : P82912 (28S ribosomal protein S11, mitochondrial) at the PDBe-KB .