MRPS28

MRPS28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS28 , MRP-S28, MRP-S35, MRPS35, HSPC007, mitochondrial ribosomal protein S28, COXPD47
External IDs	OMIM: 611990 MGI: 1913480 HomoloGene: 8519 GeneCards: MRPS28
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q21.13 Start 79,918,717 bp [1] End 80,030,289 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 A1 Start 8,867,206 bp [2] End 8,988,978 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Right adrenal gland Left adrenal gland gastrocnemius muscle islet of Langerhans left ventricle substantia nigra skeletal muscle tissue hypothalamus caudate nucleus putamen Top expressed in triceps brachii muscle sternocleidomastoid muscle temporal muscle digastric muscle soleus muscle skeletal muscle tissue extraocular muscle quadriceps femoris muscle tibialis anterior muscle thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28957 66230 Ensembl ENSG00000147586 ENSMUSG00000040269 UniProt Q9Y2Q9 Q9CY16 RefSeq (mRNA) NM_014018 NM_025434 RefSeq (protein) NP_054737 NP_079710 Location (UCSC) Chr 8: 79.92 – 80.03 Mb Chr 3: 8.87 – 8.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S28, mitochondrial is a protein that in humans is encoded by the MRPS28 gene. ^{[5] [6] [7]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000147586 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040269 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
7. "Entrez Gene: MRPS28 mitochondrial ribosomal protein S28".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• O'Brien TW, Liu J, Sylvester JE, et al. (2000). "Mammalian mitochondrial ribosomal proteins (4). Amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 275 (24): 18153–9. doi: 10.1074/jbc.M909762199 . PMID   10751423.
• Koc EC, Burkhart W, Blackburn K, et al. (2000). "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins". J. Biol. Chem. 275 (42): 32585–91. doi: 10.1074/jbc.M003596200 . PMID   10938081.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.