60S ribosomal protein L28

RPL28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AJ0, 4UG0, 4V6X, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL28 , L28, ribosomal protein L28
External IDs	OMIM: 603638; MGI: 101839; HomoloGene: 768; GeneCards: RPL28; OMA:RPL28 - orthologs
EC number	3.6.5.3
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.42 Start 55,385,932 bp [1] End 55,403,250 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 A1|7 2.77 cM Start 4,795,873 bp [2] End 4,798,065 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery oral cavity skin of thigh mucosa of paranasal sinus skin of hip trabecular bone lower lobe of lung human penis caput epididymis corpus epididymis Top expressed in urinary bladder yolk sac adrenal gland white adipose tissue bone marrow epiblast striatum of neuraxis uterus thymus spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome Cellular component cell body cytosol ribosome membrane intracellular anatomical structure dendrite cytoplasmic ribonucleoprotein granule cytosolic large ribosomal subunit extracellular exosome Biological process positive regulation of protein targeting to mitochondrion viral transcription SRP-dependent cotranslational protein targeting to membrane regulation of autophagy of mitochondrion translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6158 19943 Ensembl ENSG00000108107 ENSMUSG00000030432 UniProt P46779 P41105 RefSeq (mRNA) NM_000991 NM_001136134 NM_001136135 NM_001136136 NM_001136137 NM_001363697 NM_009081 RefSeq (protein) NP_000982 NP_001129606 NP_001129607 NP_001129608 NP_001129609 NP_001350626 NP_033107 Location (UCSC) Chr 19: 55.39 – 55.4 Mb Chr 7: 4.8 – 4.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene. ^{[5] [6] [7]}

Gene

Alternative splicing of RPL28 leads to multiple transcript variants encoding distinct isoforms. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. ^[7]

Clinical significance

Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000108107 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030432 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1262 (1): 64–68. doi:10.1016/0167-4781(95)00045-i. PMID   7772601.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, et al. (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Research. 8 (5): 509–523. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPL28 ribosomal protein L28".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochemistry and Cell Biology. 73 (11–12): 933–947. doi:10.1139/o95-101. PMID   8722009.
• Brown JR, Daar IO, Krug JR, Maquat LE (Jul 1985). "Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family". Molecular and Cellular Biology. 5 (7): 1694–1706. doi:10.1128/mcb.5.7.1694. PMC   367288 . PMID   4022011.
• Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, et al. (Dec 1994). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–250. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (Dec 2001). "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics. 17 (12). Oxford, England: 1152–1157. doi: 10.1093/bioinformatics/17.12.1152 . PMID   11751223.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (Mammalian Gene Collection Program Team) (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kasai H, Nadano D, Hidaka E, Higuchi K, Kawakubo M, Sato TA, et al. (May 2003). "Differential expression of ribosomal proteins in human normal and neoplastic colorectum". The Journal of Histochemistry and Cytochemistry. 51 (5): 567–574. doi:10.1177/002215540305100502. PMID   12704204. S2CID   25865715.
• Odintsova TI, Muller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, et al. (Apr 2003). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". Journal of Protein Chemistry. 22 (3): 249–258. doi:10.1023/A:1025068419698. PMID   12962325. S2CID   10710245.
• Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Research. 32 (8): 2411–2420. doi:10.1093/nar/gkh552. PMC   419443 . PMID   15121898.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, et al. (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1) 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Human RPL28 genome location and RPL28 gene details page in the UCSC Genome Browser .
• PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L28