EIF3J

EIF3J
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KRB, 3BPJ
Identifiers
Aliases	EIF3J , EIF3S1, eIF3-alpha, eIF3-p35, eukaryotic translation initiation factor 3 subunit J
External IDs	OMIM: 603910 MGI: 3704486 HomoloGene: 37845 GeneCards: EIF3J
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q21.1 Start 44,537,125 bp [1] End 44,563,029 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B3 Start 43,608,483 bp [2] End 43,610,861 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle biceps brachii body of pancreas sural nerve ganglionic eminence islet of Langerhans thymus body of tongue rectum monocyte Top expressed in quadriceps femoris muscle yolk sac skeletal muscle tissue placenta zone of skin secondary oocyte mirror esophagus bone marrow ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding translation initiation factor activity Cellular component cytoplasm eukaryotic translation initiation factor 3 complex cytosol eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process translational initiation protein biosynthesis formation of cytoplasmic translation initiation complex cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8669 100042807 Ensembl ENSG00000104131 ENSMUSG00000043424 UniProt O75822 Q66JS6 RefSeq (mRNA) NM_003758 NM_001284335 NM_001284336 NM_001256055 RefSeq (protein) NP_001271264 NP_001271265 NP_003749 NP_001242984 Location (UCSC) Chr 15: 44.54 – 44.56 Mb Chr 18: 43.61 – 43.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the EIF3J gene. ^{[5] [6]}

Interactions

eIF3j has been shown to interact with eIF3a. ^{[5] [7]}

See also

• Eukaryotic initiation factor 3 (eIF3)

References

1. GRCh38: Ensembl release 89: ENSG00000104131 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043424 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Block KL, Vornlocher HP, Hershey JW (Dec 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi: 10.1074/jbc.273.48.31901 . PMID   9822659.
6. "Entrez Gene: EIF3S1 eukaryotic translation initiation factor 3, subunit 1 alpha, 35kDa".
7. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi: 10.1046/j.1432-1033.2003.03807.x . PMID   14519125.

Further reading

• Asano K, Kinzy TG, Merrick WC, Hershey JW (1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". J. Biol. Chem. 272 (2): 1101–9. doi: 10.1074/jbc.272.2.1101 . PMID   8995409.
• Méthot N, Rom E, Olsen H, Sonenberg N (1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi: 10.1074/jbc.272.2.1110 . PMID   8995410.
• Bushell M, Wood W, Clemens MJ, Morley SJ (2000). "Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis". Eur. J. Biochem. 267 (4): 1083–91. doi: 10.1046/j.1432-1327.2000.01101.x . PMID   10672017.
• Valásek L, Hasek J, Nielsen KH, Hinnebusch AG (2001). "Dual function of eIF3j/Hcr1p in processing 20 S pre-rRNA and translation initiation". J. Biol. Chem. 276 (46): 43351–60. doi: 10.1074/jbc.M106887200 . PMID   11560931.
• Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi: 10.1046/j.1432-1033.2003.03807.x . PMID   14519125.
• Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW (2004). "The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro". J. Biol. Chem. 279 (10): 8946–56. doi: 10.1074/jbc.M312745200 . PMID   14688252.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• ElAntak L, Tzakos AG, Locker N, Lukavsky PJ (2007). "Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit" (PDF). J. Biol. Chem. 282 (11): 8165–74. doi: 10.1074/jbc.M610860200 . PMID   17190833.

External links

• Overview of all the structural information available in the PDB for UniProt : O75822 (Human Eukaryotic translation initiation factor 3 subunit J (EIF3J)) at the PDBe-KB .