RPL7A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | RPL7A , L7A, SURF3, TRUP, ribosomal protein L7a | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 185640 MGI: 1353472 HomoloGene: 105462 GeneCards: RPL7A | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene. [5] [6] [7]
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [7]
In molecular biology, U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets. U24 is encoded within an intron of the gene for ribosomal protein L7a in mammals, chicken and Fugu. The U76/SNORD76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene. snoRNAs Z20 and U76 snoRNAs show clear similarity to U24.
In molecular biology, snoRNA U36 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
60S ribosomal protein L5 is a protein that in humans is encoded by the RPL5 gene.
60S ribosomal protein L10 is a protein that in humans is encoded by the RPL10 gene.
40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene.
40S ribosomal protein S3a is a protein that in humans is encoded by the RPS3A gene.
60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene.
40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.
60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.
40S ribosomal protein S17 is a protein that in humans is encoded by the RPS17 gene.
60S ribosomal protein L13a is a protein that in humans is encoded by the RPL13A gene.
60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.
60S ribosomal protein L19 is a protein that in humans is encoded by the RPL19 gene.
40S ribosomal protein S20 is a protein that in humans is encoded by the RPS20 gene.
60S ribosomal protein L23a is a protein that in humans is encoded by the RPL23A gene.
40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.
40S ribosomal protein S11 is a protein that in humans is encoded by the RPS11 gene.
60S ribosomal protein L17 is a protein that in humans is encoded by the RPL17 gene.
60S ribosomal protein L30 is a protein that in humans is encoded by the RPL30 gene.
60S ribosomal protein L39 is a protein that in humans is encoded by the RPL39 gene.