Mitochondrial ribosomal protein L24

Last updated
MRPL24
PBB Protein MRPL11 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL24 , L24mt, MRP-L18, MRP-L24, mitochondrial ribosomal protein L24
External IDs OMIM: 611836; MGI: 1914957; HomoloGene: 12241; GeneCards: MRPL24; OMA:MRPL24 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024540
NM_145729

NM_026591

RefSeq (protein)

NP_078816
NP_663781

NP_080867

Location (UCSC) Chr 1: 156.74 – 156.74 Mb Chr 3: 87.83 – 87.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L24, mitochondrial is a protein that in humans is encoded by the MRPL24 gene. [5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its Escherichia coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143314 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019710 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MRPL24 mitochondrial ribosomal protein L24".

Further reading