40S ribosomal protein S28

RPS28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 5FLX, 4D61, 4UJC
Identifiers
Aliases	RPS28 , S28, DBA15, ribosomal protein S28, eS28
External IDs	OMIM: 603685 MGI: 1859516 HomoloGene: 68150 GeneCards: RPS28
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 8,321,158 bp [1] End 8,323,340 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 34,038,001 bp [2] End 34,043,536 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary stromal cell of endometrium skin of abdomen right uterine tube body of pancreas right lobe of thyroid gland left lobe of thyroid gland canal of the cervix body of stomach minor salivary gland Top expressed in yolk sac ganglionic eminence uterus bone marrow urinary bladder blastocyst adrenal gland islet of Langerhans stomach lip More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component cytosol ribosome intracellular anatomical structure small ribosomal subunit extracellular exosome nucleoplasm cytosolic small ribosomal subunit cytoplasm endoplasmic reticulum rough endoplasmic reticulum polysomal ribosome cytoplasmic side of rough endoplasmic reticulum membrane Biological process ribosome biogenesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ribosomal small subunit biogenesis ribosomal small subunit assembly maturation of SSU-rRNA protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6234 54127 Ensembl ENSG00000233927 ENSMUSG00000067288 UniProt P62857 P62858 RefSeq (mRNA) NM_001031 NM_016844 NM_001355384 RefSeq (protein) NP_001022 NP_058540 NP_001342313 Location (UCSC) Chr 19: 8.32 – 8.32 Mb Chr 17: 34.04 – 34.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S28 is a protein that in humans is encoded by the RPS28 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000233927 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067288 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hori N, Murakawa K, Matoba R, Fukushima A, Okubo K, Matsubara K (Nov 1993). "A cDNA sequence of human ribosomal protein, homologue of yeast S28". Nucleic Acids Res. 21 (18): 4394. doi:10.1093/nar/21.18.4394. PMC   310080 . PMID   8415000.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPS28 ribosomal protein S28".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein–protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.