60S ribosomal protein L3

For the programming language RPL-3, see Filetab.

RPL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0
Identifiers
Aliases	RPL3 , ASC-1, L3, TARBP-B, ribosomal protein L3
External IDs	OMIM: 604163 MGI: 1351605 HomoloGene: 747 GeneCards: RPL3
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 39,312,882 bp [1] End 39,320,389 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 79,961,992 bp [2] End 79,976,069 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary canal of the cervix stromal cell of endometrium ganglionic eminence right uterine tube skin of abdomen left uterine tube right lobe of thyroid gland gastric mucosa cerebellar hemisphere Top expressed in ovary hypothalamus ganglionic eminence lens zone of skin hippocampus proper uterus urinary bladder blastocyst pancreas More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding 5S rRNA binding RNA binding structural constituent of ribosome Cellular component ribosome focal adhesion intracellular anatomical structure extracellular exosome nucleolus nucleus cytoplasm cytosolic large ribosomal subunit cytosol protein-containing complex synapse Biological process cellular response to interleukin-4 viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing ribosomal large subunit assembly protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6122 27367 Ensembl ENSG00000100316 ENSMUSG00000060036 UniProt P39023 P27659 RefSeq (mRNA) NM_001033853 NM_000967 NM_013762 RefSeq (protein) NP_000958 NP_001029025 NP_038790 Location (UCSC) Chr 22: 39.31 – 39.32 Mb Chr 15: 79.96 – 79.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene. ^{[5] [6] [7]}

Function

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPL3 gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000100316 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060036 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ou JH, Yen TS, Wang YF, Kam WK, Rutter WJ (Jan 1988). "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells". Nucleic Acids Res. 15 (21): 8919–34. doi:10.1093/nar/15.21.8919. PMC   306413 . PMID   2891103.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A Map of 75 Human Ribosomal Protein Genes". Genome Research . 8 (5): 509–523. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPL3 ribosomal protein L3".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID   1538749. S2CID   4234345.
• Reddy TR, Suhasini M, Rappaport J, Looney DJ, Kraus G, Wong-Staal F (1995). "Molecular cloning and characterization of a TAR-binding nuclear factor from T cells". AIDS Res. Hum. Retroviruses. 11 (6): 663–9. doi:10.1089/aid.1995.11.663. PMID   7576925.
• Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID   8076819.
• Van Raay TJ, Connors TD, Klinger KW, Landes GM, Burn TC (1997). "A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region". Genomics. 37 (2): 172–6. doi:10.1006/geno.1996.0538. PMID   8921388.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Duga S, Asselta R, Malcovati M, Tenchini ML, Ronchi S, Simonic T (2000). "The intron-containing L3 ribosomal protein gene (RPL3): sequence analysis and identification of U43 and of two novel intronic small nucleolar RNAs". Biochim. Biophys. Acta. 1490 (3): 225–36. doi:10.1016/S0167-4781(99)00237-7. PMID   10684968.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID   11401437.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Odintsova TI, Müller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID   12962325. S2CID   10710245.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.