EIF2B3

EIF2B3
Identifiers
Aliases	EIF2B3 , EIF-2B, EIF2Bgamma, eukaryotic translation initiation factor 2B subunit gamma
External IDs	OMIM: 606273 MGI: 1313286 HomoloGene: 7005 GeneCards: EIF2B3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.1 Start 44,850,522 bp [1] End 44,986,722 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D1 Start 116,876,599 bp [2] End 116,944,503 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in triceps brachii muscle gastrocnemius muscle deltoid muscle vastus lateralis muscle islet of Langerhans parotid gland left ventricle tibialis anterior muscle Left adrenal gland thoracic diaphragm Top expressed in morula superior cervical ganglion autopod region hand foot yolk sac secondary oocyte ankle vastus lateralis muscle hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotidyltransferase activity translation factor activity, RNA binding protein binding translation initiation factor activity guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol eukaryotic translation initiation factor 2B complex Biological process oligodendrocyte development response to peptide hormone response to heat response to glucose biosynthetic process hippocampus development protein biosynthesis translational initiation T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8891 108067 Ensembl ENSG00000070785 ENSMUSG00000028683 UniProt Q9NR50 n/a RefSeq (mRNA) NM_001166588 NM_001261418 NM_020365 NM_001111277 NM_175135 NM_001355225 RefSeq (protein) NP_001160060 NP_001248347 NP_065098 n/a Location (UCSC) Chr 1: 44.85 – 44.99 Mb Chr 4: 116.88 – 116.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000070785 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028683 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kruger M, Beger C, Li QX, Welch PJ, Tritz R, Leavitt M, Barber JR, Wong-Staal F (Aug 2000). "Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach". Proc Natl Acad Sci U S A. 97 (15): 8566–71. Bibcode:2000PNAS...97.8566K. doi: 10.1073/pnas.97.15.8566 . PMC   26988 . PMID   10900014.
6. "Entrez Gene: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa".

Further reading

• Welsh GI, Miyamoto S, Price NT, et al. (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. doi: 10.1074/jbc.271.19.11410 . PMID   8626696.
• Gomez E, Pavitt GD (2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation". Mol. Cell. Biol. 20 (11): 3965–76. doi:10.1128/MCB.20.11.3965-3976.2000. PMC   85753 . PMID   10805739.
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID   10858531.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". J. Biol. Chem. 276 (27): 24697–703. doi: 10.1074/jbc.M011788200 . PMID   11323413.
• van der Knaap MS, Leegwater PA, Könst AA, et al. (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter". Ann. Neurol. 51 (2): 264–70. doi:10.1002/ana.10112. PMID   11835386. S2CID   1849575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Fogli A, Dionisi-Vici C, Deodato F, et al. (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology. 59 (12): 1966–8. doi:10.1212/01.wnl.0000041666.76863.47. PMID   12499492. S2CID   13129517.
• Fogli A, Rodriguez D, Eymard-Pierre E, et al. (2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. 72 (6): 1544–50. doi:10.1086/375404. PMC   1180314 . PMID   12707859.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Fogli A, Schiffmann R, Hugendubler L, et al. (2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients". Eur. J. Hum. Genet. 12 (7): 561–6. doi: 10.1038/sj.ejhg.5201189 . PMID   15054402.
• Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways". Mol. Cell. Biol. 24 (8): 3295–306. doi:10.1128/MCB.24.8.3295-3306.2004. PMC   381664 . PMID   15060152.
• Van Haren K, van der Voorn JP, Peterson DR, et al. (2004). "The life and death of oligodendrocytes in vanishing white matter disease". J. Neuropathol. Exp. Neurol. 63 (6): 618–30. doi: 10.1093/jnen/63.6.618 . PMID   15217090.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV (2006). "Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases". Biochem. Biophys. Res. Commun. 338 (4): 1766–72. doi:10.1016/j.bbrc.2005.10.150. PMID   16288713.
• Mikami S, Masutani M, Sonenberg N, et al. (2006). "An efficient mammalian cell-free translation system supplemented with translation factors". Protein Expr. Purif. 46 (2): 348–57. doi:10.1016/j.pep.2005.09.021. PMID   16289705.