60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene. [5] [6]
60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene. [5] [6]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternative splice variants encoding different isoforms may exist, but they have not been fully characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[ citation needed ]
RPL11 has been shown to interact with:
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.
p14ARF is an alternate reading frame protein product of the CDKN2A locus. p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). It accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting ribosome biogenesis or initiating p53-dependent cell cycle arrest and apoptosis, respectively. p14ARF is an atypical protein, in terms of its transcription, its amino acid composition, and its degradation: it is transcribed in an alternate reading frame of a different protein, it is highly basic, and it is polyubiquinated at the N-terminus.
60S ribosomal protein L5 is a protein that in humans is encoded by the RPL5 gene.
Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene. It is found within the nucleolus that binds p53. Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses. It is a marker for many stem cells and cancer cells.
Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.
Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene. It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA.
40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.
40S ribosomal protein S25 (eS25) is a protein that in humans is encoded by the RPS25 gene.
40S ribosomal protein S26 is a protein that in humans is encoded by the RPS26 gene.
60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.
60S ribosomal protein L23 is a protein that in humans is encoded by the RPL23 gene.
TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.
40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.
RNA, ribosomal 1, also known as RNR1, is a human gene.
RNA, ribosomal 3, also known as RNR3, is a human gene. It is a minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes the rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication.
RNA, ribosomal 5, also known as RNR5, is a human gene. Genes for ribosomal RNA are clustered on the short arms of chromosomes 13, 14, 15, 20, 21. The gene for RNR5 exists in multiple copies on chromosome 22. Each gene cluster contains 30–40 copies and encodes a 45S RNA product that is then cleaved to form 18S, 5.8S and 28S rRNA subunits. In general, genes for RNA remain poorly annotated in most large public databases.
39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.
60S ribosomal protein L26 is a protein that in humans is encoded by the RPL26 gene.
39S ribosomal protein L23, mitochondrial is a protein that in humans is encoded by the MRPL23 gene.
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