40S ribosomal protein S7

RPS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 5FLX, 4D61, 4UJC
Identifiers
Aliases	RPS7 , DBA8, S7, ribosomal protein S7, eS7
External IDs	OMIM: 603658 MGI: 1333818 HomoloGene: 107159 GeneCards: RPS7
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p25.3 Start 3,575,260 bp [1] End 3,580,920 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 A2 Start 28,680,853 bp [2] End 28,685,952 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans rectum lymph node smooth muscle tissue ganglionic eminence uterine tube skin of abdomen canal of the cervix placenta anterior pituitary Top expressed in ganglionic eminence lens lip yolk sac thymus morula spleen ovary neural tube mesencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding mRNA 3'-UTR binding mRNA 5'-UTR binding ubiquitin ligase inhibitor activity protein kinase binding poly(U) RNA binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure microtubule organizing center nucleolus extracellular exosome cytoskeleton nucleus nucleoplasm extracellular matrix cytoplasm 90S preribosome small-subunit processome centrosome cytosolic small ribosomal subunit protein-containing complex synapse ribonucleoprotein complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ribosomal small subunit biogenesis rRNA processing protein biosynthesis cytoplasmic translation positive regulation of gene expression protein stabilization positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of ubiquitin protein ligase activity negative regulation of ubiquitin-dependent protein catabolic process neural tube closure cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6201 20115 Ensembl ENSG00000171863 ENSMUSG00000061477 UniProt P62081 P62082 RefSeq (mRNA) NM_001011 NM_011300 RefSeq (protein) NP_001002 NP_035430 Location (UCSC) Chr 2: 3.58 – 3.58 Mb Chr 12: 28.68 – 28.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene. ^{[5] [6] [7]}

In eukaryotes, ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171863 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061477 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Annilo T, Laan M, Stahl J, Metspalu A (Jan 1996). "The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25". Gene. 165 (2): 297–302. doi:10.1016/0378-1119(95)00576-R. PMID   8522193.
6. Gorbea C, Taillandier D, Rechsteiner M (Feb 2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7" (PDF). J Biol Chem. 275 (2): 875–82. doi: 10.1074/jbc.275.2.875 . PMID   10625621.
7. "Entrez Gene: RPS7 ribosomal protein S7".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon". Biochim. Biophys. Acta. 1173 (3): 273–82. doi:10.1016/0167-4781(93)90124-v. PMID   8318536.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC   1170780 . PMID   9687515.
• Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC   125346 . PMID   11823430.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi: 10.4161/cc.5.6.2560 . PMID   16582619.
• Chen D, Zhang Z, Li M, et al. (2007). "Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function". Oncogene. 26 (35): 5029–37. doi:10.1038/sj.onc.1210327. PMID   17310983. S2CID   9239498.

External links

• Overview of all the structural information available in the PDB for UniProt : P62081 (40S ribosomal protein S7) at the PDBe-KB .