40S ribosomal protein S8

RPS8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4UJE, 4D5L, 3J7R, 4UJD, 5FLX, 4D61, 4UJC
Identifiers
Aliases	RPS8 , S8, ribosomal protein S8
External IDs	OMIM: 600357 MGI: 98166 HomoloGene: 133143 GeneCards: RPS8
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.1 Start 44,775,251 bp [1] End 44,778,779 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D1 Start 117,011,024 bp [2] End 117,013,440 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix uterine tube ganglionic eminence right uterine tube right adrenal gland lymph node left uterine tube skin of abdomen vagina prostate Top expressed in ganglionic eminence uterus esophagus ovary ileum duodenum lens zone of skin bone marrow pancreas More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component focal adhesion nucleus intracellular anatomical structure ribosome extracellular exosome membrane nucleoplasm cytoplasm endoplasmic reticulum cytosol cytosolic small ribosomal subunit ribonucleoprotein complex Biological process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay SRP-dependent cotranslational protein targeting to membrane viral transcription maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translational initiation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6202 20116 Ensembl ENSG00000142937 ENSMUSG00000047675 UniProt P62241 P62242 RefSeq (mRNA) NM_001012 NM_009098 RefSeq (protein) NP_001003 NP_033124 Location (UCSC) Chr 1: 44.78 – 44.78 Mb Chr 4: 117.01 – 117.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene. ^{[5] [6]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000142937 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047675 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Davies B, Fried M (Mar 1993). "The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1". Genomics. 15 (1): 68–75. doi:10.1006/geno.1993.1011. PMID   8432552.
6. "Entrez Gene: RPS8 ribosomal protein S8".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Pogue-Geile K, Geiser JR, Shu M, et al. (1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8): 3842–9. doi:10.1128/mcb.11.8.3842. PMC   361167 . PMID   1712897.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Nicoloso M, Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J. Mol. Biol. 260 (2): 178–95. doi:10.1006/jmbi.1996.0391. PMID   8764399.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Brenner C, Deplus R, Didelot C, et al. (2005). "Myc represses transcription through recruitment of DNA methyltransferase corepressor". EMBO J. 24 (2): 336–46. doi:10.1038/sj.emboj.7600509. PMC   545804 . PMID   15616584.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics. 6 (4): 575–88. doi: 10.1074/mcp.M600249-MCP200 . PMID   17220478.