60S ribosomal protein L27

RPL27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL27 , L27, ribosomal protein L27
External IDs	OMIM: 607526 MGI: 98036 HomoloGene: 105144 GeneCards: RPL27
Gene ontology Molecular function structural constituent of ribosome RNA binding protein binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure cytosolic large ribosomal subunit extracellular exosome nucleus extracellular matrix cytoplasm endoplasmic reticulum rough endoplasmic reticulum cytoplasmic side of rough endoplasmic reticulum membrane ribonucleoprotein complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing response to aldosterone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6155 19942 Ensembl ENSG00000131469 ENSMUSG00000063316 UniProt P61353 P61358 RefSeq (mRNA) NM_000988 NM_011289 RefSeq (protein) NP_000979 NP_001336850 NP_001336851 NP_035419 Location (UCSC) n/a n/a PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L27 is a protein that in humans is encoded by the RPL27 gene. ^{[3] [4]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L27E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[4]

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Jones KW, Chevrette M, Shapero MH, Fournier RE (Jun 1993). "Generation of region- and species-specific expressed gene probes from somatic cell hybrids". Nat Genet. 1 (4): 278–83. doi:10.1038/ng0792-278. PMID   1302024. S2CID   30900271.
4. "Entrez Gene: RPL27 ribosomal protein L27".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. Bibcode:1994Sci...266...66M. doi: 10.1126/science.7545954 . PMID   7545954.
• Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–66. doi:10.1093/hmg/4.8.1259. PMID   7581362.
• Gallagher RA, McClean PM, Malik AN (1994). "Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney". Biochim. Biophys. Acta. 1217 (3): 329–32. doi:10.1016/0167-4781(94)90295-x. PMID   8148381.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID   11401437.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.

External links

• Overview of all the structural information available in the PDB for UniProt : P61353 (60S ribosomal protein L27) at the PDBe-KB .