60S ribosomal protein L31

RPL31
Identifiers
Aliases	RPL31 , L31, ribosomal protein L31
External IDs	OMIM: 617415 MGI: 2149632 HomoloGene: 133014 GeneCards: RPL31
Gene location (Human)
Chr.	Chromosome 2 (human)
End	101,024,032 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	39,410,992 bp
RNA expression pattern
	Top expressed in
	caput epididymis; ; spongy bone; ; vulva; ; corpus epididymis; ; germinal epithelium; ; lactiferous duct; ; human penis; ; Achilles tendon; ; pericardium; ; vena cava;
	Top expressed in
	yolk sac; ; superior frontal gyrus; ; lip; ; morula; ; fossa; ; Paneth cell; ; primitive streak; ; condyle; ; ureter; ; ectoderm;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome ;
Cellular component	ribosome ; intracellular anatomical structure ;
Biological process	protein biosynthesis ;
	Sources:Amigo / QuickGO
Orthologs
	6160
	114641
	ENSG00000071082
	ENSMUSG00000073702
	H7C2W9
	P62900
	NM_001099693 ; NM_000993 ; NM_001098577
	NM_001252218 ; NM_001252219 ; NM_053257
	n/a
	NP_001239147 ; NP_001239148 ; NP_444487
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 22, 2024

60S ribosomal protein L31 is a protein that in humans is encoded by the RPL31 gene.^[5]^[6]^[7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Interactions

RPL31 has been shown to interact with BRCA1.^[8]

Related Research Articles

60S acidic ribosomal protein P0 is a protein that in humans is encoded by the RPLP0 gene.

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.

60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.

60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.

60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene.

60S ribosomal protein L24 is a protein that in humans is encoded by the RPL24 gene.

60S ribosomal protein L23 is a protein that in humans is encoded by the RPL23 gene.

60S ribosomal protein L13a is a protein that in humans is encoded by the RPL13A gene.

60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.

60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene.

40S ribosomal protein S11 is a protein that in humans is encoded by the RPS11 gene.

60S ribosomal protein L15 is a protein that in humans is encoded by the RPL15 gene.

60S ribosomal protein L27 is a protein that in humans is encoded by the RPL27 gene.

60S ribosomal protein L34 is a protein that in humans is encoded by the RPL34 gene.

Large ribosomal subunit protein uL22 is a protein that in humans is encoded by the RPL17 gene.

60S ribosomal protein L30 is a protein that in humans is encoded by the RPL30 gene.

60S ribosomal protein L26 is a protein that in humans is encoded by the RPL26 gene.

60S ribosomal protein L37 is a protein that in humans is encoded by the RPL37 gene.

60S ribosomal protein L27a is a protein that in humans is encoded by the RPL27A gene.

60S ribosomal protein L39 is a protein that in humans is encoded by the RPL39 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000071082 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073702 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nobori T, Hexdall LE, Carson DA (September 1989). "cDNA sequence of human ribosomal protein L31". Nucleic Acids Research. 17 (17): 7105. doi:10.1093/nar/17.17.7105. PMC 318439 . PMID 2780320.
↑ Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (March 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Research. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282 . PMID 11875025.
1 2 "Entrez Gene: RPL31 ribosomal protein L31".
↑ Yarden RI, Brody LC (2001). "Identification of proteins that interact with BRCA1 by Far-Western library screening". Journal of Cellular Biochemistry. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496. S2CID 29703139.

External links

Human RPL31 genome location and RPL31 gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : P62899 (Human 60S ribosomal protein L31) at the PDBe-KB .

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochemistry and Cell Biology. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Chester KA, Robson L, Begent RH, Talbot IC, Pringle JH, Primrose L, Macpherson AJ, Boxer G, Southall P, Malcolm AD (December 1989). "Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1009 (3): 297–300. doi:10.1016/0167-4781(89)90119-x. PMID 2597680.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (December 1994). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A map of 75 human ribosomal protein genes". Genome Research. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID 9582194.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Odintsova TI, Müller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG (April 2003). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". Journal of Protein Chemistry. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000071082 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073702 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2780320-5] Nobori T, Hexdall LE, Carson DA (September 1989). "cDNA sequence of human ribosomal protein L31". Nucleic Acids Research. 17 (17): 7105. doi:10.1093/nar/17.17.7105. PMC 318439 . PMID 2780320.

[pmid11875025-6] Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (March 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Research. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282 . PMID 11875025.

[entrez-7] 1 2 "Entrez Gene: RPL31 ribosomal protein L31".

[pmid11746496-8] Yarden RI, Brody LC (2001). "Identification of proteins that interact with BRCA1 by Far-Western library screening". Journal of Cellular Biochemistry. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496. S2CID 29703139.

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