EIF4H

Last updated
EIF4H
Protein EIF4H PDB 2dng.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EIF4H , WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H
External IDs OMIM: 603431; MGI: 1341822; HomoloGene: 32536; GeneCards: EIF4H; OMA:EIF4H - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022170
NM_031992

NM_033561
NM_001312867

RefSeq (protein)

NP_071496
NP_114381

NP_001299796
NP_291039

Location (UCSC) Chr 7: 74.17 – 74.2 Mb Chr 5: 134.65 – 134.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene. [5] [6] [7]

Contents

This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [7]

EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity. [8]

Related Research Articles

<span class="mw-page-title-main">MCM2</span> Protein-coding gene in the species Homo sapiens

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

<span class="mw-page-title-main">P2RY14</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.

<span class="mw-page-title-main">Nucleolar phosphoprotein p130</span> Protein-coding gene in the species Homo sapiens

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.

<span class="mw-page-title-main">ADAM9</span> Protein-coding gene in the species Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

<span class="mw-page-title-main">EIF3A</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

<span class="mw-page-title-main">EIF2S2</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

<span class="mw-page-title-main">EIF2B4</span> Protein-coding gene in the species Homo sapiens

Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.

<span class="mw-page-title-main">EIF2B3</span> Protein-coding gene in the species Homo sapiens

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.

<span class="mw-page-title-main">EIF4A1</span> Protein coding gene in Humans

Eukaryotic initiation factor 4A-I is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-dependant RNA helicases, and plays a critical role in the initiation of cap-dependent eukaryotic protein translation as a component of the eIF4F translation initiation complex. eIF4A1 unwinds the secondary structure of RNA within the 5'-UTR of mRNA, a critical step necessary for the recruitment of the 43S preinitiation complex, and thus the translation of protein in eukaryotes. It was first characterized in 1982 by Grifo, et al., who purified it from rabbit reticulocyte lysate.

<span class="mw-page-title-main">EIF4B</span> Protein-coding gene in humans

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.

<span class="mw-page-title-main">SF3B3</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

<span class="mw-page-title-main">CCT8</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene. The CCT8 protein is a component of the TRiC complex.

<span class="mw-page-title-main">EIF5</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

<span class="mw-page-title-main">MORF4L2</span> Protein-coding gene in the species Homo sapiens

Mortality factor 4-like protein 2 is a protein that in humans is encoded by the MORF4L2 gene.

<span class="mw-page-title-main">EIF3D</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

<span class="mw-page-title-main">EIF1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.

<span class="mw-page-title-main">EIF4A2</span> Protein-coding gene in the species Homo sapiens

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.

<span class="mw-page-title-main">IQCB1</span> Protein-coding gene in the species Homo sapiens

IQ calmodulin-binding motif-containing protein 1 is a protein that in humans is encoded by the IQCB1 gene.

The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.

<span class="mw-page-title-main">CD302</span> Protein-coding gene in the species Homo sapiens

The CD302 antigen also known as C-type lectin domain family 13 member A is a protein that in humans is encoded by the CD302 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000106682 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040731 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC (Apr 1998). "Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H". J Biol Chem. 273 (13): 7579–87. doi: 10.1074/jbc.273.13.7579 . PMID   9516461.
  6. Doepker RC, Hsu WL, Saffran HA, Smiley JR (Apr 2004). "Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H". J Virol. 78 (9): 4684–99. doi:10.1128/JVI.78.9.4684-4699.2004. PMC   387725 . PMID   15078951.
  7. 1 2 "Entrez Gene: EIF4H eukaryotic translation initiation factor 4H".
  8. "Early discovery may aid search for anti-aging drugs". 2010. Archived from the original on 2010-08-22. Retrieved 2010-08-22.

Further reading