EIF4H

EIF4H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DNG
Identifiers
Aliases	EIF4H , WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H
External IDs	OMIM: 603431 MGI: 1341822 HomoloGene: 32536 GeneCards: EIF4H
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q11.23 Start 74,174,231 bp [1] End 74,197,122 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 G2|5 74.71 cM Start 134,648,575 bp [2] End 134,668,344 bp [2]
RNA expression pattern Bgee Top expressed in pancreas parotid gland Body of pancreas cerebellar hemisphere More reference expression data BioGPS n/a
Gene ontology Molecular function translation factor activity, RNA binding GO:0001948 protein binding nucleic acid binding ribosomal small subunit binding RNA strand-exchange activity GO:0008026 helicase activity RNA strand annealing activity RNA binding translation initiation factor activity cadherin binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol eukaryotic translation initiation factor 4F complex membrane polysome Biological process translational initiation GO:0022415 viral process developmental growth sexual reproduction regulation of translational initiation protein biosynthesis eukaryotic translation initiation factor 4F complex assembly formation of translation preinitiation complex cytoplasmic translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7458	22384
Ensembl	ENSG00000106682	ENSMUSG00000040731
UniProt	Q15056	Q9WUK2
RefSeq (mRNA)	NM_022170 NM_031992	NM_033561 NM_001312867
RefSeq (protein)	NP_071496 NP_114381	NP_001299796 NP_291039
Location (UCSC)	Chr 7: 74.17 – 74.2 Mb	Chr 5: 134.65 – 134.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene. ^{[5] [6] [7]}

This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. ^[7]

EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000106682 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040731 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC (Apr 1998). "Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H". J Biol Chem. 273 (13): 7579–87. doi: 10.1074/jbc.273.13.7579 . PMID   9516461.
6. Doepker RC, Hsu WL, Saffran HA, Smiley JR (Apr 2004). "Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H". J Virol. 78 (9): 4684–99. doi:10.1128/JVI.78.9.4684-4699.2004. PMC   387725 . PMID   15078951.
7. "Entrez Gene: EIF4H eukaryotic translation initiation factor 4H".
8. "Early discovery may aid search for anti-aging drugs". 2010. Archived from the original on 2010-08-22. Retrieved 2010-08-22.

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Osborne LR, Martindale D, Scherer SW, et al. (1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics. 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID   8812460.
• Richter NJ, Rogers GW, Hensold JO, Merrick WC (2000). "Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H". J. Biol. Chem. 274 (50): 35415–24. doi: 10.1074/jbc.274.50.35415 . PMID   10585411.
• Martindale DW, Wilson MD, Wang D, et al. (2000). "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23". Mamm. Genome. 11 (10): 890–8. doi:10.1007/s003350010166. PMID   11003705. S2CID   8575994.
• Rogers GW, Richter NJ, Lima WF, Merrick WC (2001). "Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F". J. Biol. Chem. 276 (33): 30914–22. doi: 10.1074/jbc.M100157200 . PMID   11418588.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi: 10.1038/nature01782 . PMID   12853948.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Feng P, Everly DN, Read GS (2005). "mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A". J. Virol. 79 (15): 9651–64. doi:10.1128/JVI.79.15.9651-9664.2005. PMC   1181552 . PMID   16014927.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID   16094384. S2CID   20475874.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9WUK2 (Mouse Eukaryotic translation initiation factor 4H) at the PDBe-KB .