EIF4H | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | EIF4H , WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H | ||||||||||||||||||||||||
External IDs | OMIM: 603431 MGI: 1341822 HomoloGene: 32536 GeneCards: EIF4H | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
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RefSeq (protein) | |||||||||||||||||||||||||
Location (UCSC) | Chr 7: 74.17 – 74.2 Mb | Chr 5: 134.65 – 134.67 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene. [5] [6] [7]
This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [7]
EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity. [8]
Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene.
Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.
Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.
Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.
Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.
Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.
Eukaryotic initiation factor 4A-I is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-dependant RNA helicases, and plays a critical role in the initiation of cap-dependent eukaryotic protein translation as a component of the eIF4F translation initiation complex. eIF4A1 unwinds the secondary structure of RNA within the 5'-UTR of mRNA, a critical step necessary for the recruitment of the 43S preinitiation complex, and thus the translation of protein in eukaryotes. It was first characterized in 1982 by Grifo, et al., who purified it from rabbit reticulocyte lysate.
Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.
Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.
Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.
Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.
Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.
Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.
Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.
Eukaryotic translation initiation factor 5A pseudogene 1, also known as EIF5AP1, is a human gene.
Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.
Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.
Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (PCID1), is a protein that in humans is encoded by the EIF3M gene.
Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.
Eukaryotic translation initiation factor 1b is a protein that in humans is encoded by the EIF1B gene.