EIF4H | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | EIF4H , WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603431; MGI: 1341822; HomoloGene: 32536; GeneCards: EIF4H; OMA:EIF4H - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene. [5] [6] [7]
This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [7]
EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity. [8]
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.
P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.
Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.
Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.
Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.
Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.
Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.
Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.
Eukaryotic initiation factor 4A-I is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-dependant RNA helicases, and plays a critical role in the initiation of cap-dependent eukaryotic protein translation as a component of the eIF4F translation initiation complex. eIF4A1 unwinds the secondary structure of RNA within the 5'-UTR of mRNA, a critical step necessary for the recruitment of the 43S preinitiation complex, and thus the translation of protein in eukaryotes. It was first characterized in 1982 by Grifo, et al., who purified it from rabbit reticulocyte lysate.
Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.
Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.
T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene. The CCT8 protein is a component of the TRiC complex.
Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.
Mortality factor 4-like protein 2 is a protein that in humans is encoded by the MORF4L2 gene.
Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.
Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.
Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.
IQ calmodulin-binding motif-containing protein 1 is a protein that in humans is encoded by the IQCB1 gene.
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.
The CD302 antigen also known as C-type lectin domain family 13 member A is a protein that in humans is encoded by the CD302 gene.