60S ribosomal protein L26

RPL26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4V5Z, 4D5Y, 3J7O
Identifiers
Aliases	RPL26 , DBA11, L26, ribosomal protein L26
External IDs	OMIM: 603704; MGI: 106022; HomoloGene: 113207; GeneCards: RPL26; OMA:RPL26 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.1 Start 8,377,516 bp [1] End 8,383,213 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 68,792,409 bp [2] End 68,797,815 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence left ovary right ovary granulocyte monocyte lymph node corpus callosum canal of the cervix uterine tube Top expressed in medial ganglionic eminence transitional epithelium of urinary bladder hair follicle efferent ductule migratory enteric neural crest cell dermis endothelial cell of lymphatic vessel abdominal wall skin of external ear fossa More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome mRNA 5'-UTR binding Cellular component cytosol ribosome membrane large ribosomal subunit intracellular anatomical structure cytosolic large ribosomal subunit extracellular exosome nucleoplasm nucleolus cytoplasm cytosolic ribosome ribonucleoprotein complex Biological process protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit biogenesis translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing cytoplasmic translation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cellular response to UV positive regulation of translation cellular response to ionizing radiation cellular response to gamma radiation positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of translation involved in cellular response to UV Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6154 19941 Ensembl ENSG00000161970 ENSMUSG00000060938 UniProt P61254 P61255 RefSeq (mRNA) NM_000987 NM_001315530 NM_001315531 NM_009080 RefSeq (protein) NP_000978 NP_001302459 NP_001302460 NP_033106 Location (UCSC) Chr 17: 8.38 – 8.38 Mb Chr 11: 68.79 – 68.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Large ribosomal subunit protein uL24 is a protein that in humans is encoded by the RPL26 gene. ^{[5] [6]}

Function

Cytosolic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 rRNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the universal ribosomal protein uL24 family. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome and the human paralog RPL26L1 . ^[6]

Interactions

RPL26 has been shown to interact with Mdm2. ^[7]

See also

• Eukaryotic translation
• 60S ribosomal subunit

References

1. GRCh38: Ensembl release 89: ENSG00000161970 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060938 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zaman GJ (May 1993). "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6". Nucleic Acids Res. 21 (7): 1673. doi:10.1093/nar/21.7.1673. PMC   309386 . PMID   8479925.
6. "Entrez Gene: RPL26 ribosomal protein L26".
7. Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M (Oct 2008). "Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26". Mol. Cell. 32 (2): 180–9. doi:10.1016/j.molcel.2008.08.031. PMC   2587494 . PMID   18951086.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID   11401437.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L26