EEF1E1

EEF1E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UZ8, 4BL7, 4BVX, 4BVY, 5BMU
Identifiers
Aliases	EEF1E1 , AIMP3, P18, eukaryotic translation elongation factor 1 epsilon 1
External IDs	OMIM: 609206 MGI: 1913393 HomoloGene: 3161 GeneCards: EEF1E1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p24.3 Start 8,073,360 bp [1] End 8,102,559 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.3 Start 38,828,183 bp [2] End 38,843,034 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons oocyte islet of Langerhans embryo Right adrenal gland hypothalamus Left adrenal gland body of pancreas superior vestibular nucleus ganglionic eminence Top expressed in medial ganglionic eminence endocardial cushion superior cervical ganglion morula barrel cortex atrioventricular valve yolk sac interventricular septum primitive streak dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding glutathione transferase activity Cellular component nucleoplasm nucleolus nucleus cytoplasm aminoacyl-tRNA synthetase multienzyme complex cytosol Biological process positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator tRNA aminoacylation for protein translation protein biosynthesis positive regulation of cellular senescence negative regulation of cell population proliferation glutathione metabolic process cellular response to leukemia inhibitory factor positive regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9521 66143 Ensembl ENSG00000124802 ENSMUSG00000001707 UniProt O43324 Q9D1M4 RefSeq (mRNA) NM_004280 NM_001135650 NM_025380 RefSeq (protein) NP_001129122 NP_004271 NP_079656 Location (UCSC) Chr 6: 8.07 – 8.1 Mb Chr 13: 38.83 – 38.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation elongation factor 1 epsilon-1 is a protein that in humans is encoded by the EEF1E1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000124802 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001707 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC   20949 . PMID   9653160.
6. "Entrez Gene: EEF1E1 eukaryotic translation elongation factor 1 epsilon 1".

Further reading

• Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". J. Biol. Chem. 266 (23): 15398–405. doi: 10.1016/S0021-9258(18)98629-1 . PMID   1651330.
• Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID   9878398.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43". FEBS Lett. 542 (1–3): 119–24. doi: 10.1016/S0014-5793(03)00362-4 . PMID   12729910. S2CID   39222196.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Park BJ, Kang JW, Lee SW, et al. (2005). "The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR". Cell. 120 (2): 209–21. doi: 10.1016/j.cell.2004.11.054 . PMID   15680327. S2CID   12989946.

External links

• Overview of all the structural information available in the PDB for UniProt : O43324 (Human Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)) at the PDBe-KB .