40S ribosomal protein S24

RPS24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 4D61, 4D5L, 4UJD, 4UJE, 4UJC
Identifiers
Aliases	RPS24 , DBA3, S24, ribosomal protein S24, eS24
External IDs	OMIM: 602412 MGI: 98147 HomoloGene: 68148 GeneCards: RPS24
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.3 Start 78,033,760 bp [1] End 78,056,813 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A3 Start 24,537,193 bp [2] End 24,547,027 bp [2]
RNA expression pattern Bgee Top expressed in zone of skin cerebral cortex neocortex ovary appendix More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome translation initiation factor binding RNA binding Cellular component cytosol ribosome membrane intracellular anatomical structure small ribosomal subunit nucleus nucleoplasm cytosolic small ribosomal subunit Biological process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) viral transcription SRP-dependent cotranslational protein targeting to membrane erythrocyte homeostasis translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ribosomal small subunit biogenesis protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6229	20088
Ensembl	ENSG00000138326	ENSMUSG00000025290
UniProt	P62847	P62849
RefSeq (mRNA)	NM_001026 NM_001142282 NM_001142283 NM_001142284 NM_001142285 NM_033022	NM_011297 NM_207634 NM_207635 NM_001360584 NM_001360585 NM_001360586
RefSeq (protein)	NP_001017 NP_001135754 NP_001135755 NP_001135756 NP_001135757 NP_148982	NP_035427 NP_997517 NP_997518 NP_001347513 NP_001347514 NP_001347515
Location (UCSC)	Chr 10: 78.03 – 78.06 Mb	Chr 14: 24.54 – 24.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S24 is a protein that in humans is encoded by the RPS24 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138326 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025290 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jones AM, Marzella R, Rocchi M, Hewitt JE (Mar 1997). "Mapping of the human ribosomal small subunit protein gene RPS24 to the chromosome 10q22-q23 boundary". Genomics. 39 (1): 121–2. doi:10.1006/geno.1996.4442. PMID   9027498.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPS24 ribosomal protein S24".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Huang RT, Li DR, Wei J, et al. (1992). "Isolation and identification of hepatitis E virus in Xinjiang, China". J. Gen. Virol. 73 (5): 1143–8. doi: 10.1099/0022-1317-73-5-1143 . PMID   1588318.
• Brown SJ, Jewell A, Maki CG, Roufa DJ (1990). "A cDNA encoding human ribosomal protein S24". Gene. 91 (2): 293–6. doi:10.1016/0378-1119(90)90103-X. PMID   2210388.
• Xu WB, Roufa DJ (1996). "The gene encoding human ribosomal protein S24 and tissue-specific expression of differentially spliced mRNAs". Gene. 169 (2): 257–62. doi:10.1016/0378-1119(96)88652-5. PMID   8647458.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.