MRPS5

Last updated
MRPS5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS5 , MRP-S5, S5mt, mitochondrial ribosomal protein S5, 28S ribosomal protein S5, mitochondrial
External IDs OMIM: 611972; MGI: 1924971; HomoloGene: 32726; GeneCards: MRPS5; OMA:MRPS5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031902
NM_001321995
NM_001321996
NM_001321997

NM_029963

RefSeq (protein)

NP_001308924
NP_001308925
NP_001308926
NP_114108

NP_084239

Location (UCSC) Chr 2: 95.09 – 95.12 Mb Chr 2: 127.43 – 127.45 Mb
PubMed search [3] [4]
Wikidata
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28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the MRPS5 gene. [5]

Contents

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000289685 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027374 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MRPS5 mitochondrial ribosomal protein S5".

Further reading