MRPS5

MRPS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS5 , MRP-S5, S5mt, mitochondrial ribosomal protein S5, 28S ribosomal protein S5, mitochondrial
External IDs	OMIM: 611972 MGI: 1924971 HomoloGene: 32726 GeneCards: MRPS5
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q11.1 Start 95,085,369 bp [1] End 95,122,027 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 F1 Start 127,429,142 bp [2] End 127,448,749 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere pancreatic epithelial cell tibialis anterior muscle right lobe of liver gastrocnemius muscle renal medulla deltoid muscle Brodmann area 9 hypothalamus right adrenal gland Top expressed in spermatocyte lip superior frontal gyrus morula proximal tubule neural tube cerebellar cortex yolk sac thymus spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion cytosolic small ribosomal subunit mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64969 77721 Ensembl ENSG00000289685 ENSMUSG00000027374 UniProt P82675 Q99N87 RefSeq (mRNA) NM_031902 NM_001321995 NM_001321996 NM_001321997 NM_029963 RefSeq (protein) NP_001308924 NP_001308925 NP_001308926 NP_114108 NP_084239 Location (UCSC) Chr 2: 95.09 – 95.12 Mb Chr 2: 127.43 – 127.45 Mb PubMed search [3] [4]
Wikidata
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28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the MRPS5 gene. ^[5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000289685 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027374 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MRPS5 mitochondrial ribosomal protein S5".

Further reading

• Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (Aug 2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". The Journal of Biological Chemistry. 276 (35): 33181–95. doi: 10.1074/jbc.M103236200 . PMID   11402041.
• Koc EC, Burkhart W, Blackburn K, Koc H, Moseley A, Spremulli LL (Mar 2001). "Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach". Protein Science. 10 (3): 471–81. doi:10.1110/ps.35301. PMC   2374141 . PMID   11344316.
• Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (Jun 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". The Journal of Biological Chemistry. 276 (22): 19363–74. CiteSeerX   10.1.1.501.8919 . doi: 10.1074/jbc.M100727200 . PMID   11279123.

External links

• Overview of all the structural information available in the PDB for UniProt : P82675 (28S ribosomal protein S5, mitochondrial) at the PDBe-KB .