40S ribosomal protein S20

RPS20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 4D61, 4KZY, 4KZX, 4UJC, 4D5L, 4UJE, 4V5Z, 4KZZ, 4UJD
Identifiers
Aliases	RPS20 , S20, ribosomal protein S20, uS10
External IDs	OMIM: 603682 MGI: 1914677 HomoloGene: 37417 GeneCards: RPS20
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q12.1 Start 56,067,254 bp [1] End 56,074,510 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A1 Start 3,831,334 bp [2] End 3,835,665 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube abdominal fat gastric mucosa lymph node peritoneum canal of the cervix ganglionic eminence Achilles tendon right lung skin of abdomen Top expressed in lip morula yolk sac superior frontal gyrus spermatocyte spermatid neural tube thymus lens esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic small ribosomal subunit small ribosomal subunit extracellular exosome nucleoplasm extracellular matrix cytoplasm synapse Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6224 67427 Ensembl ENSG00000008988 ENSMUSG00000028234 UniProt P60866 P60867 RefSeq (mRNA) NM_001146227 NM_001023 NM_026147 RefSeq (protein) NP_001014 NP_001139699 NP_080423 Location (UCSC) Chr 8: 56.07 – 56.07 Mb Chr 4: 3.83 – 3.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S20 is a protein that in humans is encoded by the RPS20 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000008988 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028234 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
6. Chu W, Presky DH, Swerlick RA, Burns DK (May 1993). "Human ribosomal protein S20 cDNA sequence". Nucleic Acids Res. 21 (7): 1672. doi:10.1093/nar/21.7.1672. PMC   309385 . PMID   8479924.
7. "Entrez Gene: RPS20 ribosomal protein S20".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Kiss-László Z, Henry Y, Bachellerie JP, et al. (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–88. doi: 10.1016/S0092-8674(00)81308-2 . PMID   8674114. S2CID   10418885.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• De Bortoli M, Castellino RC, Lu XY, et al. (2006). "Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8". BMC Cancer. 6: 223. doi: 10.1186/1471-2407-6-223 . PMC   1578584 . PMID   16968546.
• Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics. 6 (4): 575–88. doi: 10.1074/mcp.M600249-MCP200 . PMID   17220478.
• Frum R, Busby SA, Ramamoorthy M, et al. (2007). "HDM2-binding partners: interaction with translation elongation factor EF1alpha". J. Proteome Res. 6 (4): 1410–7. doi:10.1021/pr060584p. PMC   4626875 . PMID   17373842.