40S ribosomal protein S12

RPS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X, 5A2Q, 5AJ0, 4KZY, 4D61, 5FLX, 4KZX, 4D5L, 4UJD, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS12 , S12, ribosomal protein S12
External IDs	OMIM: 603660 MGI: 98105 HomoloGene: 110750 GeneCards: RPS12
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q23.2 Start 132,814,569 bp [1] End 132,817,564 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A4 Start 23,661,081 bp [2] End 23,663,173 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node skin of abdomen canal of the cervix right uterine tube vagina subcutaneous adipose tissue right lobe of thyroid gland gastric mucosa upper lobe of left lung left uterine tube Top expressed in medial ganglionic eminence lip endocardial cushion dermis atrioventricular valve molar abdominal wall superior frontal gyrus thymus duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component ribosome cytoplasm membrane intracellular anatomical structure cytosolic small ribosomal subunit nucleoplasm cytosol Golgi apparatus intracellular membrane-bounded organelle Biological process SRP-dependent cotranslational protein targeting to membrane viral transcription nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6206 20042 Ensembl ENSG00000112306 ENSMUSG00000061983 UniProt P25398 P63323 Q6ZWZ6 RefSeq (mRNA) NM_001016 NM_011295 RefSeq (protein) NP_001007 NP_035425 Location (UCSC) Chr 6: 132.81 – 132.82 Mb Chr 10: 23.66 – 23.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112306 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061983 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res. 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC   328500 . PMID   1861993.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPS12 ribosomal protein S12".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Pogue-Geile K, Geiser JR, Shu M, et al. (1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8): 3842–9. doi:10.1128/mcb.11.8.3842. PMC   361167 . PMID   1712897.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Cheng Q, Lau WM, Chew SH, et al. (2002). "Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix". Br. J. Cancer. 86 (2): 274–81. doi:10.1038/sj.bjc.6600038. PMC   2375172 . PMID   11870519.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.