60S ribosomal protein L32

RPL32
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL32 , L32, PP9932, ribosomal protein L32
External IDs	MGI: 3644747 HomoloGene: 38347 GeneCards: RPL32
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p25.2 Start 12,834,485 bp [1] End 12,841,582 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A3 Start 20,084,236 bp [2] End 20,084,634 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon uterine tube canal of the cervix lymph node skin of abdomen smooth muscle tissue amygdala left uterine tube right uterine tube Top expressed in synovial joint ankle joint morula blastocyst proximal tubule spermatid spermatocyte lip mirror kidney More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic large ribosomal subunit polysomal ribosome Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing cellular response to dexamethasone stimulus liver regeneration cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6161 621697 Ensembl ENSG00000144713 ENSMUSG00000111356 UniProt P62910 n/a RefSeq (mRNA) NM_001007074 NM_000994 NM_001007073 NM_001101561 RefSeq (protein) NP_000985 NP_001007074 NP_001007075 n/a Location (UCSC) Chr 3: 12.83 – 12.84 Mb Chr 10: 20.08 – 20.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L32 is a protein that in humans is encoded by the RPL32 gene. ^{[5] [6]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000144713 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000111356 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vorobieva NV, Filipenko ML, Karpova GG, Mertvetsov NP, Graphodatsky AS (Sep 1997). "Assignment of the L32 ribosomal protein gene (RPL32) to human chromosome 3q13.3-->q21 by in situ hybridization". Cytogenetics and Cell Genetics. 77 (3–4): 190–191. doi:10.1159/000134573. PMID   9284913.
6. "Entrez Gene: RPL32 ribosomal protein L32".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochemistry and Cell Biology. 73 (11–12): 933–947. doi:10.1139/o95-101. PMID   8722009.
• Young JA, Trowsdale J (December 1985). "A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family". Nucleic Acids Research. 13 (24): 8883–8891. doi:10.1093/nar/13.24.8883. PMC   318958 . PMID   3866218.
• Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, et al. (December 1994). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–250. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Cross SH, Charlton JA, Nan X, Bird AP (March 1994). "Purification of CpG islands using a methylated DNA binding column". Nature Genetics. 6 (3): 236–244. doi:10.1038/ng0394-236. PMID   8012384. S2CID   12847618.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, et al. (May 1998). "A map of 75 human ribosomal protein genes". Genome Research. 8 (5): 509–523. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, et al. (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, et al. (March 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Research. 12 (3): 379–390. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Odintsova TI, Müller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, et al. (April 2003). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". Journal of Protein Chemistry. 22 (3): 249–258. doi:10.1023/A:1025068419698. PMID   12962325. S2CID   10710245.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, et al. (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–15729. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Baumbusch LO, Myhre S, Langerød A, Bergamaschi A, Geisler SB, Lønning PE, et al. (October 2006). "Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters". Molecular Cancer. 5: 47. doi: 10.1186/1476-4598-5-47 . PMC   1636663 . PMID   17054774.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.