60S ribosomal protein L8

RPL8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CCM, 4CCN, 4CCO, 4UG0, 4V6X, 5AJ0, 4D67, 3J7Q, 4Y3O, 4UJC, 3J7R, 4D5Y, 4UJE, 4UJD, 3J7P, 3J7O, 3J92, 4V5Z
Identifiers
Aliases	RPL8 , L8, ribosomal protein L8
External IDs	OMIM: 604177 MGI: 1350927 HomoloGene: 32141 GeneCards: RPL8
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.3 Start 144,789,765 bp [1] End 144,792,587 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D3 Start 76,788,278 bp [2] End 76,790,514 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ovary trachea thymus pituitary gland skin of abdomen anterior pituitary right uterine tube stromal cell of endometrium canal of the cervix ganglionic eminence Top expressed in primitive streak hair follicle abdominal wall medial ganglionic eminence maxillary prominence condyle dermis somite Paneth cell fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding structural constituent of ribosome RNA binding 5.8S rRNA binding Cellular component cytosol ribosome membrane focal adhesion large ribosomal subunit intracellular anatomical structure cytoplasm cytosolic large ribosomal subunit postsynaptic density polysomal ribosome synapse postsynapse Biological process cytoplasmic translation protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing cellular response to nerve growth factor stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6132 26961 Ensembl ENSG00000161016 ENSMUSG00000003970 UniProt P62917 P62918 RefSeq (mRNA) NM_000973 NM_033301 NM_001317771 NM_001317782 NM_012053 RefSeq (protein) NP_000964 NP_001304700 NP_001304711 NP_150644 NP_036183 Location (UCSC) Chr 8: 144.79 – 144.79 Mb Chr 15: 76.79 – 76.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000161016 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003970 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hanes J, Klaudiny J, von der Kammer H, Scheit KH (Feb 1994). "Characterization by cDNA cloning of the mRNA of human ribosomal protein L8". Biochem Biophys Res Commun. 197 (3): 1223–8. doi:10.1006/bbrc.1993.2607. PMID   7506540.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPL8 ribosomal protein L8".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Uhlein M, Weglöhner W, Urlaub H, Wittmann-Liebold B (1998). "Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies". Biochem. J. 331 (2): 423–30. doi:10.1042/bj3310423. PMC   1219371 . PMID   9531480.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Brezillon S, Lannoy V, Franssen JD, et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 278 (2): 776–83. doi: 10.1074/jbc.M206396200 . PMID   12401809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID   12962325. S2CID   10710245.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.

External links

• Overview of all the structural information available in the PDB for UniProt : P62917 (60S ribosomal protein L8) at the PDBe-KB .